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Although high level of oxidative stress has been observed frequently in patients infected with HIV or HCV, the status of oxidative stress in HIV\/HCV coinfection and its contribution to HCV liver damage have not been determined. This study involved 363 HBsAg\u2010negative, anti\u2010HCV\u2010positive former blood donors recruited from a village in central China in July 2005; of these, 140 were positive for HIV. Of these 363 subjects, 282 were successfully followed up through July 2009. HIV\/HCV\u2010coinfected subjects had higher rates of end\u2010stage liver disease\u2010related death than those monoinfected with HCV. Liver ultrasound manifestations were poor in HIV\u2010positive than in HIV\u2010negative individuals, in both chronic HCV carriers and those with resolved HCV. Serum concentrations of total glutathione (tGSH), malondialdehyde (MDA), glutathione peroxidase (GSH\u2010Px), GSSG, and reduced GSH were higher in HIV\u2010positive than HIV\u2010negative subjects. GSSG concentrations were higher in HIV\u2010infected subjects with abnormal ALT\/AST levels than in those with normal ALT\/AST levels and were associated with poorer liver ultrasound manifestations. These finding indicated that HIV infection accelerated HCV\u2010associated liver damage in HIV\/HCV\u2010coinfected individuals. Increased oxidative stress, induced primarily by HIV coinfection, may contribute to aggravated liver damage.<\/jats:p>","DOI":"10.1155\/2016\/8142431","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T21:04:04Z","timestamp":1452459844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Liver Damage in Patients with HCV\/HIV Coinfection Is Linked to HIV\u2010Related Oxidative 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