{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:54:08Z","timestamp":1787068448610,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:00Z","timestamp":1450224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Development Planning of Shandong Province","award":["2014GSF-118090"],"award-info":[{"award-number":["2014GSF-118090"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    This study aims to evaluate the cardioprotective effects of astragalin against myocardial ischemia\/reperfusion (I\/R) injury in isolated rat heart. The cardioprotective effects of astragalin on myocardial I\/R injury were investigated on Langendorff apparatus. Adult male Sprague\u2010Dawley rats were randomly divided into five groups. The results showed that astragalin pretreatment improved myocardial function. Compared with I\/R group, lactate dehydrogenase (LDH) and creatine kinase (CK) activities in coronary flow decreased in astragalin pretreatment groups, whereas superoxide dismutase (SOD) activity and glutathione\/glutathione disulfide (GSH\/GSSG) ratio significantly increased. The levels of malondialdehyde (MDA), intracellular reactive oxygen species (ROS), tumor necrosis factor\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ), and interleukin\u20106 (IL\u20106) decreased in astragalin\u2010treated groups. The infarct size (IS) and apoptosis rate in hearts from astragalin\u2010treated groups were lower than those in hearts from the I\/R group. Western blot analysis also revealed that astragalin preconditioning significantly reduced Bax level, whereas Bcl\u20102 was increased in the myocardium. Therefore, astragalin exhibited cardioprotective effects via its antioxidative, antiapoptotic, and anti\u2010inflammatory activities.\n                  <\/jats:p>","DOI":"10.1155\/2016\/8194690","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T02:11:53Z","timestamp":1450318313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Cardioprotective Effects of Astragalin against Myocardial Ischemia\/Reperfusion Injury in Isolated Rat 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