{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:51:24Z","timestamp":1784242284559,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,28]],"date-time":"2016-08-28T00:00:00Z","timestamp":1472342400000},"content-version":"vor","delay-in-days":240,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Laboratory of Digestive Pathophysiology of Zhejiang Province","award":["2012C33038"],"award-info":[{"award-number":["2012C33038"]}]},{"name":"Science Technology Department of Zhejiang Province","award":["2012C33038"],"award-info":[{"award-number":["2012C33038"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To investigate effects and possible mechanisms of transcutaneous electrical acustimulation (TEA) performed by a wearable watch\u2010size stimulator for refractory gastroesophageal reflux disease (RGERD). <jats:italic>Methods<\/jats:italic>. Twenty patients diagnosed as RGERD were enrolled in the study and randomly divided into four groups: esomeprazole group (Group A), esomeprazole combined with TEA group (Group B), esomeprazole combined with sham\u2010TEA group (Group C), and esomeprazole combined with domperidone group (Group D). HRM and 24\u2009h pH\u2010impedance monitoring and GerdQ score were used to measure related indexes before and after treatment. <jats:italic>Results<\/jats:italic>. (1) TEA significantly increased LESP, compared with PPI treatment only or PPI plus sham\u2010TEA. After pairwise comparison, LESP of Group B was increased more than Group A (<jats:italic>P<\/jats:italic> = 0.008) or Group C (<jats:italic>P<\/jats:italic> = 0.021). (2) PPI plus TEA decreased not only the number of acid reflux episodes but also the number of weak acid reflux episodes (<jats:italic>P<\/jats:italic> = 0.005). (3) Heartburn and reflux symptoms were improved more with PPI + TEA than with PPI treatment only or PPI plus sham\u2010TEA (GerdQ scores, <jats:italic>P<\/jats:italic> = 0.001). <jats:italic>Conclusion<\/jats:italic>. TEA can improve symptoms in RGERD patients by increasing LESP and decreasing events of weak acid reflux and acid reflux; addition of TEA to esomeprazole significantly enhances the effect of TEA.<\/jats:p>","DOI":"10.1155\/2016\/8246171","type":"journal-article","created":{"date-parts":[[2016,8,28]],"date-time":"2016-08-28T21:05:25Z","timestamp":1472418325000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of Transcutaneous Electrical Acustimulation on Refractory Gastroesophageal Reflux Disease"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2015-5742","authenticated-orcid":false,"given":"Li-na","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6433-2184","authenticated-orcid":false,"given":"Shanshan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0191-5697","authenticated-orcid":false,"given":"Jiande D. 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