{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:59:00Z","timestamp":1788850740595,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["10ZR1425900"],"award-info":[{"award-number":["10ZR1425900"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["2009202"],"award-info":[{"award-number":["2009202"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007279","name":"Shanghai Municipal Health Bureau","doi-asserted-by":"publisher","award":["10ZR1425900"],"award-info":[{"award-number":["10ZR1425900"]}],"id":[{"id":"10.13039\/501100007279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007279","name":"Shanghai Municipal Health Bureau","doi-asserted-by":"publisher","award":["2009202"],"award-info":[{"award-number":["2009202"]}],"id":[{"id":"10.13039\/501100007279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Chronic periodontitis (CP) is one of the most common chronic inflammatory diseases and cytokines play a pivotal role in the regulation of immune response. Interleukin-4 (IL-4) and interleukin-13 (IL-13) are anti-inflammatory cytokines and several polymorphisms of them have been proved involved in periodontal disease. This study aimed to evaluate whether three single nucleotide polymorphisms (SNPs), rs2070874 and rs2243248 from<jats:italic>IL4<\/jats:italic>and rs1800925 from<jats:italic>IL13<\/jats:italic>, are associated with CP in a Han Chinese population consisting of 440 moderate or severe CP patients and 324 healthy controls. Genomic DNA extracted from buccal epithelial cells of the included participants were genotyped using a matrix-assisted laser desorption\/ionization time-of-flight (MALDI-TOF) mass spectrometry method. No significant association between rs2070874 or rs1800925 and CP was found, while the frequencies of rs2243248 and two haplotypes C-G-T and C-T-T showed significant differences between the two groups. The results suggest that the polymorphism rs2243248 and haplotypes C-G-T and C-T-T may be associated with CP susceptibility in the present Han Chinese population.<\/jats:p>","DOI":"10.1155\/2016\/8389020","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T21:03:08Z","timestamp":1461013388000},"page":"1-7","source":"Crossref","is-referenced-by-count":11,"title":["Association between Polymorphisms in Interleukins 4 and 13 Genes and Chronic Periodontitis in a Han Chinese Population"],"prefix":"10.1155","volume":"2016","author":[{"given":"Dong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Periodontology, Shanghai Stomatological Disease Center, Shanghai 200001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medicine Research Center, Weifang Medical University, Weifang 261053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Weifang Medical University, Weifang 261053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(05)67728-8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.2006.00953.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2001.2260106.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400605"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00198.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027009682.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-s.2042"},{"key":"8","first-page":"28","volume":"94","year":"1994","journal-title":"Current Opinion in Periodontology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1159\/000087104"},{"issue":"115","key":"10","first-page":"93","volume":"20","year":"2006","journal-title":"Polski Merkuriusz Lekarski"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009016"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1126\/science.8178175"},{"issue":"7","key":"13","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1182\/blood.V76.7.1392.1392","volume":"76","year":"1990","journal-title":"Blood"},{"issue":"1","key":"14","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0021-9258(18)48525-0","volume":"267","year":"1992","journal-title":"The Journal of Biological Chemistry"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(92)90056-i"},{"issue":"6","key":"16","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.4049\/jimmunol.148.6.1812","volume":"148","year":"1992","journal-title":"Journal of Immunology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.11.1699"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.03204.x"},{"issue":"12","key":"19","first-page":"1379","volume":"65","year":"1985","journal-title":"Journal of Dental Research"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.327"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb00428.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.4.12tac-14"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.024"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.4103\/0971-6866.112891"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2011.02.005"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090392"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.2007.01086.x"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016522"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.143123"},{"issue":"3","key":"30","first-page":"273","volume":"29","year":"2011","journal-title":"Asian Pacific Journal of Allergy and Immunology"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1159\/000314366"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6_part2.610"},{"issue":"1","key":"33","first-page":"6","volume":"18","year":"2000","journal-title":"Journal of Forensic Odonto-Stomatology"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.103457"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290272"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2361"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080035"},{"key":"38","year":"1976"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01241-3"},{"issue":"4","key":"40","first-page":"1239","volume":"142","year":"1993","journal-title":"The American Journal of Pathology"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2006.07.020"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1996.tb00295.x"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1997.tb01391.x"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01166.x"},{"key":"45","first-page":"354","volume-title":"Analogous mechanism of tissue destruction in rheumatoid arthritis and periodontal disease","year":"1982"},{"issue":"8","key":"46","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.4049\/jimmunol.151.8.4344","volume":"151","year":"1993","journal-title":"The Journal of Immunology"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb01729.x"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1994.tb00074.x"},{"issue":"11","key":"49","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.4049\/jimmunol.151.11.6370","volume":"151","year":"1993","journal-title":"The Journal of Immunology"},{"issue":"3","key":"50","first-page":"422","volume":"103","year":"1996","journal-title":"Clinical and Experimental Immunology"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302x.1997.tb00392.x"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-9969(99)00094-1"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1038\/ng749"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.1.23"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595x.1997.tb00680.x"},{"key":"56","first-page":"12","volume":"1","year":"1994","journal-title":"Current Opinion in Periodontology"},{"issue":"1","key":"57","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-051X.1997.tb01187.x","volume":"24","year":"1997","journal-title":"Journal of Clinical Periodontology"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(03)12516-0"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/8389020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/8389020.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/8389020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T20:49:58Z","timestamp":1718484598000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2016\/8389020\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":58,"alternative-id":["8389020","8389020"],"URL":"https:\/\/doi.org\/10.1155\/2016\/8389020","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}