{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T12:27:04Z","timestamp":1749126424946,"version":"3.41.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anemia"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Iron deposition in the body can damage the endocrine glands of patients with<jats:italic>\u03b2<\/jats:italic>-thalassaemia major (<jats:italic>\u03b2<\/jats:italic>-TM). Leptin plays a key role in the regulation of appetite, body fat mass, and endocrine function.<jats:italic>Objectives<\/jats:italic>. This study aimed to evaluate the relationship between serum leptin and growth and pubertal development in patients with<jats:italic>\u03b2<\/jats:italic>-TM, as well as whether serum leptin can predict growth retardation and delayed puberty in these patients.<jats:italic>Methods<\/jats:italic>. Fifty<jats:italic>\u03b2<\/jats:italic>-TM patients (aged 8\u201320 years) and 75 age-matched healthy controls were recruited. Anthropometric data and sexual maturity ratings were assessed. Serum leptin was measured by ELISA.<jats:italic>Results<\/jats:italic>. Serum leptin levels were significantly lower in patients with<jats:italic>\u03b2<\/jats:italic>-TM than in healthy individuals (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). Leptin levels were also significantly reduced in female patients with short stature (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.002<\/mml:mn><\/mml:math>) and in patients who displayed delayed puberty (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.032<\/mml:mn><\/mml:math>) compared to those with normal stature who had reached puberty. The sensitivity of leptin for predicting short stature and delayed puberty among patients was 84.6% and 92.3%, respectively.<jats:italic>Conclusion<\/jats:italic>. Low serum leptin is sensitive to predict short stature and significant in<jats:italic>\u03b2<\/jats:italic>-TM females only. This link could thus be used as a guide for further therapeutic or hormonal modulation.<\/jats:p>","DOI":"10.1155\/2016\/8454286","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T22:41:17Z","timestamp":1458600077000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Serum Leptin Levels and Growth in Patients with<i>\u03b2<\/i>-Thalassaemia Major"],"prefix":"10.1155","volume":"2016","author":[{"given":"Lamia Mustafa","family":"Al-Naama","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Haemoglobinopathy Units, College of Medicine, University of Basrah, Basrah, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meaad Kadum","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Haemoglobinopathy Units, College of Medicine, University of Basrah, Basrah, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhannad Maki","family":"Abdul Karim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, University of Basrah, Basrah, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"first-page":"535","volume-title":"Thalassemia 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