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We investigated the effects of alcoholic extract of<jats:italic>A. adstringens<\/jats:italic>(AaEE) in DSS-induced colitis in mice. The protective effect of AaEE was determined at 200\u2009mg\/kg by oral gavage for 10 days. We determine the effect of AaEE on clinical features (disease activity index), antioxidants, anti-inflammatory, and immunomodulatory activities in relation to the activity of SOD, CAT, and GPx, levels of proinflammatory cytokines, and changes both macroscopic and microscopic of the colonic mucosa. AaEE significantly reduced the inflammation of colon and significantly increased SOD and GPx activities. AaEE also significantly decreased TNF-<jats:italic>\u03b1<\/jats:italic>, IFN-<jats:italic>\u03b3<\/jats:italic>, and IL-1<jats:italic>\u03b2<\/jats:italic>cytokine levels compared to DSS-treated mice and reduced both infiltration of inflammatory cells and the mucosal damage in colon. The results suggested the protective potential of AaEE in DSS-induced colitis and this might be attributed to its phytochemicals compounds that have been found to induce a wide spectrum of activities such as reduction in oxidative stress, suppression of inflammation, modulating numerous signal transduction pathways, and induction of apoptosis. The findings of this study suggest that AaEE has substantial potential for the treatment of inflammatory colitis.<\/jats:p>","DOI":"10.1155\/2016\/8543561","type":"journal-article","created":{"date-parts":[[2016,8,21]],"date-time":"2016-08-21T17:01:22Z","timestamp":1471798882000},"page":"1-12","source":"Crossref","is-referenced-by-count":22,"title":["Protective Effect of<i>Amphipterygium adstringens<\/i>Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice"],"prefix":"10.1155","volume":"2016","author":[{"given":"Mario","family":"Rodriguez-Canales","sequence":"first","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Prolongaci\u00f3n de Carpio y Plan de Ayala s\/n, 11400 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Jimenez-Rivas","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunobiolog\u00eda, 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