{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:41:20Z","timestamp":1777606880678,"version":"3.51.4"},"reference-count":8,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Aubrey Sage McFarlane acute lung injury","award":["UM1 HL116885-02"],"award-info":[{"award-number":["UM1 HL116885-02"]}]},{"name":"VCU Johnson Center for Critical Care","award":["UM1 HL116885-02"],"award-info":[{"award-number":["UM1 HL116885-02"]}]},{"name":"Pulmonary Research","award":["UM1 HL116885-02"],"award-info":[{"award-number":["UM1 HL116885-02"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 HL116885-02"],"award-info":[{"award-number":["UM1 HL116885-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Critical Care"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>This case report summarizes the first use of intravenous vitamin C employed as an adjunctive interventional agent in the therapy of<jats:italic> recurrent<\/jats:italic> acute respiratory distress syndrome (ARDS). The two episodes of ARDS occurred in a young female patient with Cronkhite-Canada syndrome, a rare, sporadically occurring, noninherited disorder that is characterized by extensive gastrointestinal polyposis and malabsorption. Prior to the episodes of sepsis, the patient was receiving nutrition via chronic hyperalimentation administered through a long-standing central venous catheter. The patient became recurrently septic with Gram positive cocci which led to two instances of ARDS. This report describes the broad-based general critical care of a septic patient with acute respiratory failure that includes fluid resuscitation, broad-spectrum antibiotics, and vasopressor support. Intravenous vitamin C infused at 50\u2009mg per kilogram body weight every 6 hours for 96 hours was incorporated as an adjunctive agent in the care of this patient. Vitamin C when used as a parenteral agent in high doses acts \u201cpleiotropically\u201d to attenuate proinflammatory mediator expression, to improve alveolar fluid clearance, and to act as an antioxidant.<\/jats:p>","DOI":"10.1155\/2016\/8560871","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T16:07:46Z","timestamp":1478534866000},"page":"1-4","source":"Crossref","is-referenced-by-count":20,"title":["Intravenous Vitamin C Administered as Adjunctive Therapy for Recurrent Acute Respiratory Distress Syndrome"],"prefix":"10.1155","volume":"2016","author":[{"given":"Amit","family":"Bharara","sequence":"first","affiliation":[{"name":"Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Grossman","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7620-6166","authenticated-orcid":true,"given":"Daniel","family":"Grinnan","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aamer","family":"Syed","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-2025","authenticated-orcid":true,"given":"Bernard","family":"Fisher","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"DeWilde","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3431-9971","authenticated-orcid":true,"given":"Ramesh","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1445-8800","authenticated-orcid":true,"given":"Alpha A. (Berry)","family":"Fowler","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200212000-00014"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.135.3.326"},{"key":"3","volume":"17, article s153","year":"1989","journal-title":"Critical Care Medicine"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-12-32"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0b013e3182120cb8"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113497760"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00300.2011"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/mco.0000000000000148"}],"container-title":["Case Reports in Critical Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cricc\/2016\/8560871.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cricc\/2016\/8560871.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cricc\/2016\/8560871.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T16:07:53Z","timestamp":1478534873000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cricc\/2016\/8560871\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":8,"alternative-id":["8560871","8560871"],"URL":"https:\/\/doi.org\/10.1155\/2016\/8560871","relation":{},"ISSN":["2090-6420","2090-6439"],"issn-type":[{"value":"2090-6420","type":"print"},{"value":"2090-6439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}