{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:16:20Z","timestamp":1790612180908,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"vor","delay-in-days":272,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273741"],"award-info":[{"award-number":["81273741"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>We systematically assess the current clinical evidence of Gualouxiebaibanxia (GLXBBX) decoction for the treatment of angina pectoris (AP). We included RCTs testing GLXBBX against conventional drugs and GLXBBX combined with conventional drugs versus conventional drugs. 19 RCTs involving 1730 patients were finally identified, and the methodological quality was evaluated as generally low. The results of the meta\u2010analysis showed that GLXBBX alone had significant effect on improving angina symptoms (RR: 1.24, 95% CI 1.14 to 1.35; <jats:italic>P<\/jats:italic> &lt; 0.00001), ECG (RR: 1.28 [1.13,1.44]; <jats:italic>P<\/jats:italic> &lt; 0.0001), and HDL\u2010C (MD: 0.56 [0.54,0.58]; <jats:italic>P<\/jats:italic> &lt; 0.00001) compared with anti\u2010arrhythmic drugs. A significant improvement in angina symptoms (RR: 1.17 [1.12,1.22]; <jats:italic>P<\/jats:italic> &lt; 0.00001) and ECG (RR = 1.22; 95% CI = [1.14,1.30]; <jats:italic>P<\/jats:italic> &lt; 0.00001) was observed for GLXBBX plus conventional drugs when compared with conventional drugs. Eight trials reported adverse events without serious adverse effects. GLXBBX appears to have beneficial effects on improvement of ECG and reduction of angina symptoms in participants with AP. However, the evidence remains weak due to the poor methodological quality of the included studies. More rigorous trials are needed to confirm the results.<\/jats:p>","DOI":"10.1155\/2016\/8565907","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T22:22:26Z","timestamp":1475187746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Effect of Chinese Herbal Medicine Gualouxiebaibanxia Decoction for the Treatment of Angina Pectoris: A Systematic Review"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-9493","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6874-8344","authenticated-orcid":false,"given":"Xingjiang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6306-7665","authenticated-orcid":false,"given":"Xiaochen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3213-265X","authenticated-orcid":false,"given":"Fuyong","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4198-7417","authenticated-orcid":false,"given":"Hongxu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,29]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/suq014"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.113.001258"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22479"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(14)61682-2"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-015-0173-4"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.192703"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38695.605440.ae"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl001"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.295"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000143379.26342.5C"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.13-1-63"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2015.042"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.12.008"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/619706"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12102"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(12)60015-6"},{"key":"e_1_2_10_17_2","first-page":"433","article-title":"Study on the active spirostanol saponins of Gualou xiebai baijiutang","volume":"38","author":"He X. J.","year":"2003","journal-title":"Yao Xue Xue Bao"},{"key":"e_1_2_10_18_2","first-page":"567","article-title":"Pharmacodynamics Study on gualou xiebai dropping pills and its medicinal ingredients in prescription","volume":"38","author":"Yan H.-Y.","year":"2015","journal-title":"Zhong Yao Cai"},{"key":"e_1_2_10_19_2","first-page":"40","article-title":"Clinical observation of Gualou xiebai banxia Decoction on angina pectoris","volume":"10","author":"Chen G. X.","year":"2008","journal-title":"Hubei Journal of Traditional Chinese Medicine"},{"key":"e_1_2_10_20_2","first-page":"64","article-title":"Clinical observation and analysis of Gualou xiebai banxia Decoction for 48 cases of angina","volume":"25","author":"Bai J. M.","year":"2007","journal-title":"Journal of Sichuan of Traditional Chinese Medicine"},{"key":"e_1_2_10_21_2","first-page":"1530","article-title":"Clinical observation of Gualou xiebai banxia Decoction for 32 cases of angina","volume":"16","author":"Yang J. D.","year":"2007","journal-title":"JETCM"},{"key":"e_1_2_10_22_2","first-page":"454","article-title":"Clinical observation on 36 cases of angina pectoris of coronary heart disease treated by gualou xiebai banxia decoction","volume":"7","author":"Hu X. F.","year":"2001","journal-title":"Hunan Guiding Journal of TCMP"},{"key":"e_1_2_10_23_2","first-page":"770","article-title":"Clinical observation of Gualou xiebai banxia Decoction for 56 cases with angina pectoris of coronary heart disease","volume":"25","author":"Zhang D. F.","year":"2013","journal-title":"Clinical Journal of Traditional Chinese Medicine"},{"key":"e_1_2_10_24_2","first-page":"62","article-title":"Clinical observation on treating 58 cases of angina pectoris of coronary heart disease with gualouxiebaibanxia decoction addition","volume":"12","author":"He Y. H.","year":"2006","journal-title":"Guiding Journal of TCM"},{"key":"e_1_2_10_25_2","first-page":"11","article-title":"Observation of gualou xiebai banxia decoction combined with western medicine treating 45 cases of coronary heart disease angina pectoris","volume":"33","author":"Shi P. F.","year":"2013","journal-title":"Modern Traditional Chinese Medicine"},{"key":"e_1_2_10_26_2","first-page":"1101","article-title":"Clinical observation of flavored gualou xiebai and banxia decoction in the treatment of unstable angina of coronary heart disease","volume":"27","author":"Si J. X.","year":"2012","journal-title":"China Journal of Chinese Medicine"},{"key":"e_1_2_10_27_2","first-page":"927","article-title":"Clinical observation on 68 cases of angina pectoris of coronary heart disease treated by gualou xiebai banxia decoction","volume":"27","author":"Wang Z. Z.","year":"2012","journal-title":"CJGMCM"},{"key":"e_1_2_10_28_2","first-page":"248","article-title":"Clinical observation of Gualou xiebai banxia decoction for 60 cases with angina pectoris of coronary heart disease","volume":"13","author":"Zhang Z. Q.","year":"2003","journal-title":"Zhejiang JITCWM"},{"key":"e_1_2_10_29_2","first-page":"418","article-title":"Observation of gualou xiebai banxia decoction combined with western medicine treating 34 cases of coronary heart disease angina pectoris","volume":"46","author":"Fang H. B.","year":"2011","journal-title":"Zhejiang Journal of Traditional Chinese Medicine"},{"key":"e_1_2_10_30_2","first-page":"1256","article-title":"Clinical observation and analysis of Gualou xiebai banxia Decoction for 80 cases with angina pectoris of coronary heart disease","volume":"27","author":"Zhu B. G.","year":"2012","journal-title":"CJGMCM"},{"key":"e_1_2_10_31_2","first-page":"846","article-title":"Clinical observation of Flavored Gualou xiebai banxia Decoction for angina pectoris of coronary heart disease","volume":"15","author":"Li J. L.","year":"2011","journal-title":"Public Medical Forum Magazine"},{"key":"e_1_2_10_32_2","first-page":"2439","article-title":"Therapeutic effects of Flavored Gualou xiebai banxia Decoction for 42 patients of angina pectoris of phlegm and blood stasis syndrome","volume":"30","author":"Zhang H. W.","year":"2015","journal-title":"CJGMCM"},{"key":"e_1_2_10_33_2","first-page":"110","article-title":"Randomized parallel group study Gualou Xiebai soup combined with Western treatment of Angina Pectoris","volume":"29","author":"Ma P.","year":"2015","journal-title":"Journal of Practical Traditional Chinese Internal Medicine"},{"key":"e_1_2_10_34_2","first-page":"228","article-title":"Clinical observation of Gualouxiebaibanxia Decoction combined with Nitroglycerin Injection for 42 cases with angina pectoris of coronary heart disease","volume":"13","author":"Yang Q. F.","year":"2015","journal-title":"Guide of Chinese Medicine"},{"key":"e_1_2_10_35_2","first-page":"62","article-title":"Phlegm method for unstable angina plasma ox-LDL levels affect random parallel control study","volume":"27","author":"Tong R. X.","year":"2013","journal-title":"Journal of Practical Traditional Chinese Internal Medicine"},{"key":"e_1_2_10_36_2","first-page":"1033","article-title":"Clinical observation of Gualou xiebai banxia Decoction for angina pectoris of coronary heart disease","volume":"21","author":"Wang W. Q.","year":"2015","journal-title":"Heibei Medicine"},{"key":"e_1_2_10_37_2","first-page":"125","article-title":"Clinical observation of modified Gualou xiebai banxia Decoction for 80 cases with angina pectoris of coronary heart disease","volume":"23","author":"Yang F. Q.","year":"2015","journal-title":"China Medical Engineering"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.59.3.607"},{"key":"e_1_2_10_39_2","first-page":"149","article-title":"ACC\/AHA practice guidelines-ACC\/AHA 2002 guideline update for the management of patients with chronic stable angina task force on practice guidelines (committee to update the 1999 guidelines)","volume":"107","author":"Gibbons R. J.","year":"2002","journal-title":"Circulation"},{"key":"e_1_2_10_40_2","unstructured":"HigginsJ. P. T.andGreenS. Corchrane Reviewers\u2032 Handbook 5.1.0 [updated March 2011] Review Manager (RevMan) [Computer program]. Version 5.1.0."},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.2174\/157340212803530411"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-011-0643-6"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-015-1228-y"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/circoutcomes.114.001063"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.m010330"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2014.05.008"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.16.11.1347"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/75.1.119"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37641-0"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04244.x"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135228"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516x.179017"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000000352"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/8565907.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/8565907.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/8565907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T01:27:52Z","timestamp":1722907672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/8565907"}},"subtitle":[],"editor":[{"given":"Giuseppe","family":"Caminiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/8565907"],"URL":"https:\/\/doi.org\/10.1155\/2016\/8565907","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2016-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8565907"}}