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The major threat of these brain diseases includes progressive loss of memory, Alzheimer\u2019s disease (AD), impairments in the movement, Parkinson\u2019s disease (PD), and the inability to walk, talk, and think, Huntington\u2019s disease (HD). Oxidative stress and mitochondrial dysfunction are highlighted as a central feature of brain degenerative diseases. Oxidative stress, a condition that occurs due to imbalance in oxidant and antioxidant status, has been known to play a vital role in the pathophysiology of neurodegenerative diseases including AD, PD, and HD. A large number of studies have utilized oxidative stress biomarkers to investigate the severity of these neurodegenerative diseases and medications are available, but these only treat the symptoms. In traditional medicine, a large number of medicinal plants have been used to treat the symptoms of these neurodegenerative diseases. Extensive studies scientifically validated the beneficial effect of natural products against neurodegenerative diseases using suitable animal models. This short review focuses the role of oxidative stress in the pathogenesis of AD, PD, and HD and the protective efficacy of natural products against these diseases.<\/jats:p>","DOI":"10.1155\/2016\/8590578","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T16:07:14Z","timestamp":1482854834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":477,"title":["The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer\u2019s Disease, Parkinson\u2019s Disease, and Huntington\u2019s Disease: A Mini Review"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5233-9071","authenticated-orcid":false,"given":"Shanmugam","family":"Manoharan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8105-4470","authenticated-orcid":false,"given":"Gilles J.","family":"Guillemin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajagopal Selladurai","family":"Abiramasundari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musthafa Mohamed","family":"Essa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8820-7406","authenticated-orcid":false,"given":"Mohammed","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed D.","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,27]]},"reference":[{"key":"e_1_2_15_1_2","doi-asserted-by":"publisher","DOI":"10.2174\/157015909787602823"},{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70159-9"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05292"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2004.tb00087.x"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.219"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1427.007"},{"key":"e_1_2_15_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(05)67889-0"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1427.010"},{"key":"e_1_2_15_9_2","first-page":"48","article-title":"Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer\u2032s disease and correlation with APOE","volume":"119","author":"Joseph F. 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