{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:20:43Z","timestamp":1793164843500,"version":"4.5.0"},"reference-count":108,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Specific autoimmune and inflammatory rheumatic diseases have been associated with an increased risk of malignant lymphomas. Conditions such as rheumatoid arthritis (RA), primary Sj\u00f6gren\u2019s syndrome (pSS), systemic lupus erythematosus (SLE), dermatomyositis, and celiac disease have been consistently linked to malignant lymphomas. Isolated cases of lymphomas associated with spondyloarthropathies and autoinflammatory diseases have also been reported. Direct association between autoimmunity and lymphomagenesis has been reinforced by large epidemiological studies. It is still uncertain whether disease specific determinants or phenotypic or treatment related characteristics increase likelihood of lymphomagenesis in these patients. For example, recent literature has indicated a positive correlation between severity of inflammation and risk of lymphomas among RA and Sj\u00f6gren\u2019s syndrome patients. It is also debated whether specific lymphoma variants are more commonly seen in accordance with certain chronic autoimmune arthritis. Previous studies have revealed a higher incidence of diffuse large B-cell lymphomas in RA and SLE patients, whereas pSS has been linked with increased risk of mucosa-associated lymphoid tissue lymphoma. This review summarizes recent literature evaluating risk of lymphomas in arthritis patients and disease specific risk determinants. We also elaborate on the association of autoimmune arthritis with specific lymphoma variants along with genetic, environmental, and therapeutic risk factors.<\/jats:p>","DOI":"10.1155\/2016\/8631061","type":"journal-article","created":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T18:08:02Z","timestamp":1467137282000},"page":"1-11","source":"Crossref","is-referenced-by-count":36,"title":["Autoimmune\/Inflammatory Arthritis Associated Lymphomas: Who Is at Risk?"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8799-1801","authenticated-orcid":true,"given":"Sujani","family":"Yadlapati","sequence":"first","affiliation":[{"name":"Rheumatology Division, New York Methodist Hospital, Brooklyn, NY 11215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8923-7837","authenticated-orcid":true,"given":"Petros","family":"Efthimiou","sequence":"additional","affiliation":[{"name":"Rheumatology Division, New York Methodist Hospital, Brooklyn, NY 11215, USA"},{"name":"Weill Cornell Medical College, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(01)00486-7"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.epi-06-0300"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2008.02029.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/art.21675"},{"key":"5","year":"2001"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1002\/art.11144"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj004"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1002\/art.22277"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07011.x"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101190"},{"issue":"3","key":"6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/1097-0215(20001101)88:3<497::AID-IJC27>3.0.CO;2-J","volume":"88","year":"2000","journal-title":"International Journal of Cancer"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.149419"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/art.10939"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.08.006"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/art.20311"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken130"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24287"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.085852"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9298-y"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/art.27402"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.08.006"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes350"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201969"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep404"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.04.006"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200402"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21887"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203305"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2002.004721"},{"key":"25","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1136\/ard.2003.006056","volume":"63","year":"2004","journal-title":"Annals of the Rheumatic Diseases"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.08.028"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.047514"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1002\/art.23267"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/art.23185"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/art.38385"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1191\/096120301678416079"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1191\/096120301678646128"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1080\/03009740252937568"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1422.008"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9151-8"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1332-7"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1002\/art.30483"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.12.009"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(00)03540-6"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1699"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02655.x"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01520.x"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1002\/art.22579"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.030528"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.033241"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1002\/art.22056"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1002\/art.20311"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1002\/art.23716"},{"issue":"2","key":"47","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1182\/blood.V90.2.766","volume":"90","year":"1997","journal-title":"Blood"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199908)42:8<1765::aid-anr28>3.0.co;2-v"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04993.x"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-10-1100"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1002\/art.27564"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.05.014"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.62"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1002\/art.21029"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830211114"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2009.02237.x"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2004.05.001"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000027506.55846.5d"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-1-199401010-00006"},{"issue":"9","key":"62","first-page":"S188","volume":"41","year":"1998","journal-title":"Arthritis & Rheumatology"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018472213872"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.041186"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1097\/md.0b013e3181b76ab5"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.04.006"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.10.002"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090835"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.144782"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1080\/030097401316909486"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.034504"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202099"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0532-7"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.067108"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.069039"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199202063260602"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700410"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.006056"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.878016"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-015-0624-5"},{"issue":"2","key":"81","first-page":"322","volume":"34","year":"2007","journal-title":"Journal of Rheumatology"},{"issue":"6","key":"82","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1200\/JCO.1996.14.6.1943","volume":"14","year":"1996","journal-title":"Journal of Clinical Oncology"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.093690"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.049460"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.19.2275"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1002\/art.10679"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-012-0158-0"},{"issue":"6","key":"94","first-page":"411","volume":"93","year":"1996","journal-title":"Acta Neurologica Scandinavica"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1159\/000079947"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.18.1360"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg105"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.5.9904045"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12040906"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.10.892"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.6064\/2012\/215308"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.2741\/1710"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl388"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-012-0098-4"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2224-4"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1097\/cej.0b013e328355ed08"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201484"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.6227"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.2001.0442"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/8631061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/8631061.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/8631061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T02:05:03Z","timestamp":1600826703000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2016\/8631061\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":108,"alternative-id":["8631061","8631061"],"URL":"https:\/\/doi.org\/10.1155\/2016\/8631061","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}