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Matrigel invasion assay showed that cell invasion of uveal melanoma cells could be significantly inhibited by zeaxanthin. Secretion of MMP-2 by melanoma cells was significantly inhibited by zeaxanthin in a dose-dependent manner as measured by ELISA kit. Zeaxanthin also significantly inhibited the NF-<jats:italic>\u03ba<\/jats:italic>B levels in nuclear extracts of the UM cells, which is the upstream of the MMP-2 secretion. 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