{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:08:14Z","timestamp":1778558894017,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Object<\/jats:italic>. To test whether preoperative immunonutrition is efficacious in reducing postoperative complications in patients of thymoma with myasthenia gravis (MG).<jats:italic>Material and Methods<\/jats:italic>. A total of 244 patients operated on for thymoma with myasthenia gravis were prospectively assigned to two groups, each receiving seven-day preoperative and seven-day postoperative nutrition. The patients in immunonutrition group were given oral immunonutrition (IN). The patients in control group received oral standard nutrition. Immunonutritional and inflammatory biomarkers (IgA, IgG, IgM, CD3t, CD4t, CD8t, CD4t\/CD8t ratio, NK-cell, prealbumin, albumin, white blood cells counts, and C-reactive protein) and clinical variables (age, gender, BMI, performance status, type of thymoma, type of MG, operative time, pathology, operative approach, postoperative complications, quantity of drainage, hospital stays) were examined.<jats:italic>Results<\/jats:italic>. A significant reduction in the length of hospital stay, quantity of drainage, and postoperative complications was observed in the IN group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). An increase in the level of IgA, IgG, IgM, CD3+T, CD4+T, CD4+T\/CD8+T, WBC, CRP, and NK-cell in the IN group was observed after thymectomy, while a decrease was seen with regard to prealbumin and albumin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. Preoperative immunonutrition support is effective in reducing postoperative complications in patients of thymoma with MG. It helps to lower the risk of postoperative infectious complications and hospital stays.<\/jats:p>","DOI":"10.1155\/2016\/8781740","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T16:02:23Z","timestamp":1478793743000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["The Effect of Immunonutrition on the Postoperative Complications in Thymoma with Myasthenia Gravis"],"prefix":"10.1155","volume":"2016","author":[{"given":"Yanzhong","family":"Xin","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihui","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute for the Control of Agrochemicals, Ministry of Agriculture, Beijing 100125, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7434-3888","authenticated-orcid":true,"given":"Youbin","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-012-0318-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2012.08.002"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03019.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.03.055"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/jto.0b013e3181a4b8e0"},{"issue":"2","key":"6","first-page":"130","volume":"17","year":"2014","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/bf03218097"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(01)03080-6"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.74"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050135"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050059"},{"key":"12","first-page":"457","volume-title":"Disorders of neuromuscular transmission","year":"2008"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.163863"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2050.1999.00074.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s005950170005"},{"issue":"12","key":"16","first-page":"1958","volume":"36","year":"2009","journal-title":"Gan To Kagaku Ryoho"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3088-1"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9407-7"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/s0261-5614(02)00215-7"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33587"},{"key":"21","volume":"12","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"12","key":"22","year":"2013","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1254.053"},{"issue":"4","key":"24","first-page":"453","volume":"52","year":"2004","journal-title":"Neurology India"},{"key":"25","first-page":"351","volume-title":"Treatment of the critically ill patient with myasthenia gravis","year":"2016"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-4-12"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1986.01400090026004"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.128350"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(98)00103-8"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.09.012"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2016.38"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.01.006"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000003704"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2016.05.071"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/s1878-7886(15)30005-9"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000001311"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1385\/NCC:3:3:213"},{"issue":"11","key":"38","first-page":"302","volume":"106","year":"2015","journal-title":"Fukuoka Igaku Zasshi"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2015.49"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.11.003"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2912418"},{"issue":"1","key":"42","doi-asserted-by":"crossref","first-page":"C47","DOI":"10.1152\/ajpcell.1992.263.1.C47","volume":"263","year":"1992","journal-title":"American Journal of Physiology-Cell Physiology"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000278064.32780.d3"},{"issue":"5","key":"44","doi-asserted-by":"crossref","first-page":"G943","DOI":"10.1152\/ajpgi.1997.272.5.G943","volume":"272","year":"1997","journal-title":"American Journal of Physiology\u2014Gastrointestinal and Liver Physiology"},{"issue":"2","key":"45","first-page":"331","volume":"108","year":"1990","journal-title":"Surgery"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.467"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0756-8"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2016\/8781740.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2016\/8781740.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2016\/8781740.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T09:16:35Z","timestamp":1568538995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2016\/8781740\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":47,"alternative-id":["8781740","8781740"],"URL":"https:\/\/doi.org\/10.1155\/2016\/8781740","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}