{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:40:29Z","timestamp":1789558829053,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["3060282"],"award-info":[{"award-number":["3060282"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Z201306"],"award-info":[{"award-number":["Z201306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2012-WS-055"],"award-info":[{"award-number":["2012-WS-055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Health in Jiangsu Province of China","award":["3060282"],"award-info":[{"award-number":["3060282"]}]},{"name":"Department of Health in Jiangsu Province of China","award":["Z201306"],"award-info":[{"award-number":["Z201306"]}]},{"name":"Department of Health in Jiangsu Province of China","award":["2012-WS-055"],"award-info":[{"award-number":["2012-WS-055"]}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["3060282"],"award-info":[{"award-number":["3060282"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["Z201306"],"award-info":[{"award-number":["Z201306"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["2012-WS-055"],"award-info":[{"award-number":["2012-WS-055"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>The molecular mechanism of bone marrow mesenchymal stromal stem cells (BMSCs) mobilization and migration to the liver was poorly understood. Stromal cell\u2010derived factor\u20101 (SDF\u20101) participates in BMSCs homing and migration into injury organs. We try to investigate the role of SDF\u20101 signaling in BMSCs migration towards injured liver. The expression of CXCR4 in BMSCs at mRNA level and protein level was confirmed by RT\u2010PCR, flow cytometry, and immunocytochemistry. The SDF\u20101 or liver lysates induced BMSCs migration was detected by transwell inserts. CXCR4 antagonist, AMD3100, and anti\u2010CXCR4 antibody were used to inhibit the migration. The Sprague\u2010Dawley rat liver injury model was established by intraperitoneal injection of thioacetamide. The concentration of SDF\u20101 increased as modeling time extended, which was determined by ELISA method. The Dir\u2010labeled BMSCs were injected into the liver of the rats through portal vein. The cell migration in the liver was tracked by <jats:italic>in vivo<\/jats:italic> imaging system and the fluorescent intensity was measured. <jats:italic>In vivo<\/jats:italic>, BMSCs migrated into injured liver which was partially blocked by AMD3100 or anti\u2010CXCR4 antibody. Taken together, the results demonstrated that the migration of BMSCs was regulated by SDF\u20101\/CXCR4 signaling which involved in BMSCs recruitment to injured liver.<\/jats:p>","DOI":"10.1155\/2016\/8906945","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T23:20:37Z","timestamp":1452640837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Stromal Derived Factor\u20101\/CXCR4 Axis Involved in Bone Marrow Mesenchymal Stem Cells Recruitment to Injured Liver"],"prefix":"10.1155","volume":"2016","author":[{"given":"Kuai","family":"Xiao Ling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Jian Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wei Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan","family":"Cheng Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Zhi Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,12]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.71"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-472x(02)00820-2"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2003.09.007"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062363"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.111.082453"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-9"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.01.021"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0085"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs132"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-011-9293-z"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-011-1097-z"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2007.05.007"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/153623002321025014"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2604rev"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403184"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.20-6-530"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.2131\/jts.34.27"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.040"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22236"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.44"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1782"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-0941"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0319"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0526"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(03)14232-8"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147780.30124.CF"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.19-5-453"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci200317902"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368911x605367"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.03.003"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i6.507"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03703"}],"container-title":["Stem Cells International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2016\/8906945.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2016\/8906945.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/8906945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T02:07:35Z","timestamp":1722910055000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/8906945"}},"subtitle":[],"editor":[{"given":"Shinn-Zong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/8906945"],"URL":"https:\/\/doi.org\/10.1155\/2016\/8906945","archive":["Portico"],"relation":{},"ISSN":["1687-966X","1687-9678"],"issn-type":[{"value":"1687-966X","type":"print"},{"value":"1687-9678","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2015-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8906945"}}