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If increased to levels which cannot be neutralized by the defense mechanisms, they damage biological molecules, alter their functions, and also act as signaling molecules thus generating a spectrum of pathologies. In this review, we summarize current data on oxidative stress markers associated with human immunodeficiency virus type\u20101 (HIV\u20101) infection, analyze mechanisms by which this virus triggers massive ROS production, and describe the status of various defense mechanisms of the infected host cell. In addition, we have scrutinized scarce data on the effect of ROS on HIV\u20101 replication. Finally, we present current state of knowledge on the redox alterations as crucial factors of HIV\u20101 pathogenicity, such as neurotoxicity and dementia, exhaustion of CD4\n                    <jats:sup>+<\/jats:sup>\n                    \/CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cells, predisposition to lung infections, and certain side effects of the antiretroviral therapy, and compare them to the pathologies associated with the nitrosative stress.\n                  <\/jats:p>","DOI":"10.1155\/2016\/8910396","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T17:33:18Z","timestamp":1476379998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":324,"title":["Oxidative Stress during HIV Infection: Mechanisms and 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