{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T06:29:13Z","timestamp":1763620153455,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T00:00:00Z","timestamp":1458086400000},"content-version":"vor","delay-in-days":75,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2014M3A9D7034335","K15101"],"award-info":[{"award-number":["NRF-2014M3A9D7034335","K15101"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","award":["NRF-2014M3A9D7034335","K15101"],"award-info":[{"award-number":["NRF-2014M3A9D7034335","K15101"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. To investigate whether dyspepsia symptoms differ depending on the presence or absence of cold hypersensitivity in the hands and feet (CHHF). <jats:italic>Methods<\/jats:italic>. In all, 6044 patients were recruited and provided with a questionnaire about CHHF and dyspepsia. Based on their responses, subjects were divided into a CHHF group (persons who noted cold sensations; <jats:italic>n<\/jats:italic> = 1209) and a non\u2010CHHF group (persons who noted warm or intermediate sensations; <jats:italic>n<\/jats:italic> = 1744). The groups were compared in terms of their usual digestion status, using chi\u2010square tests and logistic regression analyses to calculate the propensity score and odds ratios (ORs). We analyzed the participants\u2019 responses to questions on dyspepsia symptoms. <jats:italic>Results<\/jats:italic>. After matching, chi\u2010square tests indicated that the CHHF group had higher frequencies of the following symptoms: bad digestion, poor appetite, discomfort in the upper abdomen, motion sickness, epigastric burning, postprandial fullness, nausea, and bloating. Additionally, CHHF was associated with an increased OR for dyspepsia (bad digestion, vomiting, motion sickness, epigastric burning, postprandial fullness, nausea, epigastric pain, and bloating) compared with the non\u2010CHHF group. <jats:italic>Conclusion<\/jats:italic>. This study confirmed that CHHF patients have elevated frequencies of most dyspepsia symptoms.<\/jats:p>","DOI":"10.1155\/2016\/8948690","type":"journal-article","created":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T21:03:29Z","timestamp":1458162209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cold Hypersensitivity in the Hands and Feet May Be Associated with Functional Dyspepsia: Results of a Multicenter Survey Study"],"prefix":"10.1155","volume":"2016","author":[{"given":"Kwang-Ho","family":"Bae","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Ah","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Hyang","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8879-142X","authenticated-orcid":false,"given":"Youngseop","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siwoo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,16]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/768492"},{"volume-title":"WHO International Standard Terminologies on Traditional Medicine in the Western Pacific Region","year":"2007","author":"World Health Organization","key":"e_1_2_9_2_2"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2009.0331"},{"key":"e_1_2_9_4_2","first-page":"97","article-title":"Efficacy and safety of herb medication according to cold-heat tendency of knee osteoarthritis patients","volume":"29","author":"Song J. Y.","year":"2012","journal-title":"The Journal of Korean Acupuncture & Moxibustion Medicine Society"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1375\/twin.15.2.166"},{"key":"e_1_2_9_6_2","first-page":"2000","article-title":"Cold constitution: analysis of the questionnaire","volume":"39","author":"Kondo M.","year":"1987","journal-title":"Nihon Sanka Fujinka Gakkai Zasshi"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.3.235"},{"key":"e_1_2_9_8_2","first-page":"62","article-title":"A study on the correlation of cold hypersensitivity and common health indexes in young women","volume":"24","author":"Choi S.-Y.","year":"2011","journal-title":"Korean Journal of Obstetrics & Gynecology"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.15204\/jkobgy2014.27.1.140"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0553-3"},{"key":"e_1_2_9_11_2","first-page":"1","article-title":"Functional dyspepsia and subgroups in Korea and short term outcome of therapeutic trial of cisapride; Multicenter study","volume":"4","author":"Huh C.","year":"1998","journal-title":"Journal of Neurogastroenterology and Motility"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2008.ii1"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199610000-00006"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.09.028"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/832824"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.008"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365521003592663"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-12-85"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/657013"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/492941"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.2147\/clep.s75482"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/8948690.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/8948690.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/8948690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:58:59Z","timestamp":1722905939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/8948690"}},"subtitle":[],"editor":[{"given":"Sunoh","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/8948690"],"URL":"https:\/\/doi.org\/10.1155\/2016\/8948690","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"type":"print","value":"1741-427X"},{"type":"electronic","value":"1741-4288"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2015-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8948690"}}