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But it has been found to be endogenously generated from metabolism of sulfur\u2010containing amino acids in mammals through transamination by aspartate aminotransferase (AAT). SO\n                    <jats:sub>2<\/jats:sub>\n                    could be produced in cardiovascular tissues catalyzed by its synthase AAT. In recent years, studies revealed that SO\n                    <jats:sub>2<\/jats:sub>\n                    had physiological effects on the cardiovascular system, including vasorelaxation and cardiac function regulation. In addition, the pathophysiological effects of SO\n                    <jats:sub>2<\/jats:sub>\n                    were also determined. For example, SO\n                    <jats:sub>2<\/jats:sub>\n                    ameliorated systemic hypertension and pulmonary hypertension, prevented the development of atherosclerosis, and protected against myocardial ischemia\u2010reperfusion (I\/R) injury and isoproterenol\u2010induced myocardial injury. These findings suggested that endogenous SO\n                    <jats:sub>2<\/jats:sub>\n                    was a novel gasotransmitter in the cardiovascular system and provided a new therapy target for cardiovascular diseases.\n                  <\/jats:p>","DOI":"10.1155\/2016\/8961951","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T16:17:20Z","timestamp":1451405840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["Endogenous Sulfur Dioxide: A New Member of Gasotransmitter Family in the Cardiovascular 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