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H<jats:sub>2<\/jats:sub>S exerts universal cytoprotective effects and acts as a defense mechanism in organisms ranging from bacteria to mammals. It is produced by the enzymes cystathionine <jats:italic>\u03b2<\/jats:italic>\u2010synthase (CBS), cystathionine <jats:italic>\u03d2<\/jats:italic>\u2010lyase (CSE), 3\u2010mercaptopyruvate sulfurtransferase (MST), and D\u2010amino acid oxidase (DAO), which are also involved in tissue\u2010specific biochemical pathways for H<jats:sub>2<\/jats:sub>S production in the human body. H<jats:sub>2<\/jats:sub>S exerts a wide range of pathological and physiological functions in the human body, from endocrine system and cellular longevity to hepatic protection and kidney function. 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