{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:58:40Z","timestamp":1788422320828,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T00:00:00Z","timestamp":1448841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Federal Ministry for Education and Research","award":["01GN0967"],"award-info":[{"award-number":["01GN0967"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>The Wnt signalling pathway plays a crucial role in the development of the nervous system. This signalling cascade is initiated upon binding of the secreted Wnt ligand to a member of the family of frizzled receptors. In the present study, we analysed the presence of frizzled\u20104 in the enteric nervous system of human infants. Frizzled\u20104 could be identified by immunohistochemistry in a subpopulation of enteric neuronal and glial cells in the small and large intestine. Detection of frizzled\u20104 in the tunica muscularis by RT\u2010PCR confirmed this receptor\u2019s expression on the mRNA level. Interestingly, we observed distinct cell populations that co\u2010expressed frizzled\u20104 with the intermediate filament protein nestin and the neurotrophin receptor p75<jats:sup>NTR<\/jats:sup>, which have been reported to be expressed in neural progenitor cells. Flow cytometry analysis revealed that 60% of p75<jats:sup>NTR<\/jats:sup> positive cells of the tunica muscularis were positive for frizzled\u20104. Additionally, in pathological samples of Hirschsprung\u2019s disease, the expression of this Wnt receptor correlated with the number of myenteric ganglion cells and decreased from normoganglionic to aganglionic areas of large intestine. The expression pattern of frizzled\u20104 indicates that this Wnt receptor could be involved in postnatal development and\/or function of the enteric nervous system.<\/jats:p>","DOI":"10.1155\/2016\/9076823","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T21:45:43Z","timestamp":1448919943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Expression of the Wnt Receptor Frizzled\u20104 in the Human Enteric Nervous System of Infants"],"prefix":"10.1155","volume":"2016","author":[{"given":"Katharina","family":"Nothelfer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Obermayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Belz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Reinartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra M.","family":"Bareiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-J\u00f6rg","family":"B\u00fchring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi","family":"Beschorner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Just","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,30]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2003.08.002"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3184"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.234"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-1023-2"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-12-23"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.32"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.scs.0000180285.51365.55"},{"key":"e_1_2_9_8_2","first-page":"5","article-title":"Developmental disorders of the enteric nervous system: genetic and molecular bases","volume":"39","author":"Gariepy C. 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