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To investigate the influence of<jats:italic>in vitro<\/jats:italic>vibratory stimulation of human tonsillar mononuclear cells (TMCs).<jats:italic>Methods<\/jats:italic>. Fourteen IgA nephropathy (IgAN) patients with chronic tonsillitis (CT) and 12 CT patients with no renal pathology were enrolled. Group A TMCs were collected after 24 hours of culture and used to determine baseline levels. TMCs in groups B, C, D, E, and F were exposed to vibratory stimulation (60\u2009Hz) for 0 (as the control group), 1, 3, 5, and 10 minutes, respectively.<jats:italic>Results<\/jats:italic>. Baseline concentrations of B-cell-activation factor (BAFF) and IgA1, BAFF mRNA expression, and aberrant O-glycosylation IgA1 level were higher in the IgAN group as compared to that in the CT group, and all increased after vibratory stimulation. Baseline mRNA expressions of core<jats:italic>\u03b2<\/jats:italic>1,3-galactosyltransferase (C1GALT1) and core<jats:italic>\u03b2<\/jats:italic>1,3GalT-specific molecular chaperone (Cosmc) were lower in the IgAN group; the levels decreased further after vibratory stimulation.<jats:italic>Conclusion<\/jats:italic>. In patients with IgAN, vibratory stimulation of TMCs appears to induce IgA1 secretion through activation of BAFF release and to aberrant O-glycosylation IgA1 by suppressing C1GALT1 and Cosmc expression.<jats:italic>In vitro<\/jats:italic>vibratory stimulation of human TMCs mimics the vibratory simulation of palatine tonsils produced by vocal cords during phonation.<\/jats:p>","DOI":"10.1155\/2016\/9125960","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T21:29:55Z","timestamp":1473370195000},"page":"1-8","source":"Crossref","is-referenced-by-count":14,"title":["Vibration Induces BAFF Overexpression and Aberrant O-Glycosylation of IgA1 in Cultured Human Tonsillar Mononuclear Cells in IgA Nephropathy"],"prefix":"10.1155","volume":"2016","author":[{"given":"Muyao","family":"Ye","sequence":"first","affiliation":[{"name":"Nephrology Department, 2nd Xiangya Hospital, Central South University, Key Lab of Kidney Disease and Blood Purification, Changsha, 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