{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:06:11Z","timestamp":1791302771703,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,6]],"date-time":"2015-12-06T00:00:00Z","timestamp":1449360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Military Medicine and Public Health Plan","award":["CLZ120GA23"],"award-info":[{"award-number":["CLZ120GA23"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    Juvenile idiopathic arthritis (JIA), known as Juvenile rheumatoid arthritis, is the most common type of arthritis in children aged under 17. It may cause sequelae due to lack of effective treatment. The goal of this study is to explore the therapeutic effect of umbilical cord mesenchymal stem cells (UC\u2010MSCs) for JIA. Ten JIA patients were treated with UC\u2010MSCs and received second infusion three months later. Some key values such as 28\u2010joint disease activity score (DAS28), TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u20106, and regulatory T cells (Tregs) were evaluated. Data were collected at 3 months and 6 months after first treatment. DAS28 score of 10 patients was between 2.6 and 3.2 at three months after infusion. WBC, ESR, and CRP were significantly decreased while Tregs were remarkably increased and IL\u20106 and TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    were declined. Similar changes of above values were found after 6 months. At the same time, the amount of NSAIDS and steroid usage in patients was reduced. However, no significant changes were found comparing the data from 3 and 6 months. These results suggest that UC\u2010MSCs can reduce inflammatory cytokines, improve immune network effects, adjust immune tolerance, and effectively alleviate the symptoms and they might provide a safe and novel approach for JIA treatment.\n                  <\/jats:p>","DOI":"10.1155\/2016\/9165267","type":"journal-article","created":{"date-parts":[[2015,12,6]],"date-time":"2015-12-06T16:02:25Z","timestamp":1449417745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy"],"prefix":"10.1155","volume":"2016","author":[{"given":"Liming","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,6]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.13.1722"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23683"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.13.1671"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.71"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/793823"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1670"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2010.0576"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.269"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-069716"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2013.0023"},{"key":"e_1_2_9_11_2","first-page":"579","article-title":"Development of a disease activity score based on judgment in clinical practice by rheumatologists","volume":"20","author":"Van Der Heijde D. M. F. M.","year":"1993","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0321"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600855905"},{"key":"e_1_2_9_14_2","volume-title":"Juvenile Rheumatoid Arthritis","author":"William C.","year":"2012"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1586\/1744666x.2015.1032257"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/292109"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1042\/bsr20150025"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12459"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2015.2191"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368915X687543"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/439808"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12259"},{"key":"e_1_2_9_23_2","first-page":"1017","article-title":"Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials","volume":"91","author":"Lu L.-L.","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_9_24_2","series-title":"Methods in Molecular Biology","first-page":"107","volume-title":"Cellular Cardiomyoplasty","author":"Atoui R.","year":"2015"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/676903"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27548"}],"container-title":["Stem Cells International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2016\/9165267.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2016\/9165267.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/9165267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T22:06:21Z","timestamp":1722895581000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/9165267"}},"subtitle":[],"editor":[{"given":"Kathryn","family":"McFadden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,6]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/9165267"],"URL":"https:\/\/doi.org\/10.1155\/2016\/9165267","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726077742.793533209","asserted-by":"object"}]},"ISSN":["1687-966X","1687-9678"],"issn-type":[{"value":"1687-966X","type":"print"},{"value":"1687-9678","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,6]]},"assertion":[{"value":"2015-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9165267"}}