{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:06:01Z","timestamp":1791522361935,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. We aimed to assess the variation of insulin sensitivity in relation to obesity in women living with PCOS in a sub-Sahara African setting.<jats:italic>Methods<\/jats:italic>. We studied body composition, insulin sensitivity, and resting energy expenditure in 14 PCOS patients (6 obese and 8 nonobese) compared to 10 matched nonobese non-PCOS subjects. Insulin sensitivity was assessed using the gold standard 80\u2009mU\/m<jats:sup>2<\/jats:sup>\/min euglycemic-hyperinsulinemic clamp and resting energy expenditure was measured by indirect calorimetry.<jats:italic>Results<\/jats:italic>. Insulin sensitivity adjusted to lean mass was lowest in obese PCOS subjects and highest in healthy subjects (11.2<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mo stretchy=\"false\">[<\/mml:mo><\/mml:mrow><\/mml:math>10.1\u201312.4<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mo stretchy=\"false\">]<\/mml:mo><\/mml:mrow><\/mml:math>versus 12.9<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mo stretchy=\"false\">[<\/mml:mo><\/mml:mrow><\/mml:math>12.1\u201313.8<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mo stretchy=\"false\">]<\/mml:mo><\/mml:mrow><\/mml:math>versus 16.6<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mo stretchy=\"false\">[<\/mml:mo><\/mml:mrow><\/mml:math>13.8\u201317.9<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mo stretchy=\"false\">]<\/mml:mo><\/mml:mrow><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.012<\/mml:mn><\/mml:math>); there was a tendency for resting energy expenditure adjusted for total body mass to decrease across the groups highest in obese PCOS subjects (1411<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:mo stretchy=\"false\">[<\/mml:mo><\/mml:mrow><\/mml:math>1368\u20131613<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mrow><mml:mo stretchy=\"false\">]<\/mml:mo><\/mml:mrow><\/mml:math>versus 1274<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mrow><mml:mo stretchy=\"false\">[<\/mml:mo><\/mml:mrow><\/mml:math>1174\u20131355<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mrow><mml:mo stretchy=\"false\">]<\/mml:mo><\/mml:mrow><\/mml:math>versus 1239<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mrow><mml:mo stretchy=\"false\">[<\/mml:mo><\/mml:mrow><\/mml:math>1195\u20131454<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><mml:mrow><mml:mo stretchy=\"false\">]<\/mml:mo><\/mml:mrow><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.306<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. In this sub-Saharan population, insulin resistance is associated with PCOS per se but is further aggravated by obesity. Obesity did not seem to be explained by low resting energy expenditure suggesting that dietary intake may be a determinant of the obesity in this context.<\/jats:p>","DOI":"10.1155\/2016\/9201701","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T17:29:16Z","timestamp":1473355756000},"page":"1-6","source":"Crossref","is-referenced-by-count":16,"title":["The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp Study"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6934-0172","authenticated-orcid":true,"given":"Emmanuella","family":"Doh","sequence":"first","affiliation":[{"name":"National Obesity Center, Yaound\u00e9 Central Hospital, Yaound\u00e9, Cameroon"},{"name":"Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 1, Yaound\u00e9, 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