{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:38:07Z","timestamp":1787495887117,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T00:00:00Z","timestamp":1473120000000},"content-version":"vor","delay-in-days":249,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Traditional Korean Medicine R&D Project","award":["HI12C1889"],"award-info":[{"award-number":["HI12C1889"]}]},{"name":"Traditional Korean Medicine R&D Project","award":["HI13C0530"],"award-info":[{"award-number":["HI13C0530"]}]},{"name":"Ministry of Health & Welfare","award":["HI12C1889"],"award-info":[{"award-number":["HI12C1889"]}]},{"name":"Ministry of Health & Welfare","award":["HI13C0530"],"award-info":[{"award-number":["HI13C0530"]}]},{"name":"Ministry of Health & Welfare","award":["HI12C1889"],"award-info":[{"award-number":["HI12C1889"]}]},{"name":"Ministry of Health & Welfare","award":["HI13C0530"],"award-info":[{"award-number":["HI13C0530"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    Hyeonggaeyeongyo\u2010tang (HYT) is an ancient formula of oriental medicine traditionally used to treat rhinitis; however, clinical evidence has not yet been established. The aim of this study was to investigate the short\u2010term and long\u2010term efficacy and safety of HYT for chronic rhinitis. Adult subjects with chronic rhinitis symptoms were recruited. The subjects received HYT for 4 weeks and had follow\u2010up period of 8 weeks. Any medicines used to treat nasal symptoms were not permitted during the study. The skin prick test was performed to distinguish the subjects with allergic rhinitis from those with nonallergic rhinitis. After treatment, the total nasal symptoms score and the Rhinoconjunctivitis Quality of Life Questionnaire score significantly improved in the whole subject group, in the allergic rhinitis group, and in the nonallergic rhinitis group, with no adverse events. This improvement lasted during a follow\u2010up period of 8 weeks. Total IgE and eosinophil levels showed no significant difference after treatment in the allergic rhinitis group. HYT improved nasal symptoms and quality of life in patients with allergic rhinitis and nonallergic rhinitis. This is the first clinical study to evaluate the use of HYT to treat patients with rhinitis. This trial has been registered with the ClinicalTrials.gov Identifier\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02477293\">NCT02477293<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1155\/2016\/9202675","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T17:11:16Z","timestamp":1473181876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hyeonggaeyeongyo\u2010Tang for Treatment of Allergic and Nonallergic Rhinitis: A Prospective, Nonrandomized, Pre\u2010Post 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