{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:51:54Z","timestamp":1777909914655,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004600","name":"Kyungpook National University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Osteonecrosis of the femoral head (ONFH) is a complex and multifactorial disease that is influenced by a number of genetic factors in addition to environmental factors. Some autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD), are associated with the development of ONFH. Complement receptor type 2 (<jats:italic>CR2<\/jats:italic>) is membrane glycoprotein which binds C3 degradation products generated during complement activation.<jats:italic>CR2<\/jats:italic>has many important functions in normal immunity and is assumed to play a role in the development of autoimmune disease. We investigated whether<jats:italic>CR2<\/jats:italic>gene polymorphisms are associated with risk of ONFH in SLE patients. Eight polymorphisms in the<jats:italic>CR2<\/jats:italic>gene were genotyped using TaqMan<jats:italic>\u2122<\/jats:italic>assays in 150 SLE patients and 50 ONFH in SLE patients (SLE_ONFH). The association analysis of genotyped SNPs and haplotypes was performed with ONFH. It was found that three SNPs, rs3813946 in 5\u2032-UTR (untranslated region), rs311306 in intron 1, and rs17615 in exon 10 (nonsynonymous SNP; G\/A, Ser639Asn) of the<jats:italic>CR2<\/jats:italic>gene, were associated with an increased risk of ONFH under recessive model (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>values; 0.004~0.016). Haplotypes were also associated with an increased risk (OR; 3.73~) of ONFH in SLE patients. These findings may provide evidences that<jats:italic>CR2<\/jats:italic>contributes to human ONFH susceptibility in Korean SLE patients.<\/jats:p>","DOI":"10.1155\/2016\/9208035","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T18:31:29Z","timestamp":1467311489000},"page":"1-6","source":"Crossref","is-referenced-by-count":10,"title":["Association of Complement Receptor 2 Gene Polymorphisms with Susceptibility to Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus"],"prefix":"10.1155","volume":"2016","author":[{"given":"Tae-Ho","family":"Kim","sequence":"first","affiliation":[{"name":"Biomedical Research Institute, Kyungpook National University Hospital, 135 Dongdeok-ro, Jung-gu, Daegu 700-721, Republic of Korea"},{"name":"Skeletal Diseases Genome Research Center, Kyungpook National University, 135 Dongdeok-ro, Jung-gu, Daegu 700-721, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Cheol","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 17 Haengdang-Dong, Seongdong-Gu, Seoul 133-792, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Science & Biotechnology, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Skeletal Diseases Genome Research Center, Kyungpook National University, 135 Dongdeok-ro, Jung-gu, Daegu 700-721, Republic of Korea"},{"name":"Department of Orthopedic Surgery, Graduate School of Medicine, Kyungpook National University, 130 Dongdeok-ro, Jung-gu, Daegu 700-721, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8909-3287","authenticated-orcid":true,"given":"Seung-Hoon","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Graduate School of Medicine, Kyungpook National University, 130 Dongdeok-ro, Jung-gu, Daegu 700-721, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2002.33724b"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.138.5.750"},{"issue":"4","key":"3","first-page":"654","volume":"24","year":"1997","journal-title":"Journal of Rheumatology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-64-4-759"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(74)90018-3"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocl.2004.02.003"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00324.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-008-0147-1"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4000"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-013-1966-6"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.27"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205584"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2012.04.013"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-004-0186-y"},{"issue":"9","key":"15","first-page":"1725","volume":"40","year":"1997","journal-title":"Arthritis and Rheumatism"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609101104"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem321"},{"issue":"4","key":"18","first-page":"783","volume":"30","year":"2003","journal-title":"The Journal of Rheumatology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1080\/10623320600904211"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.1.165"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520140106"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.57"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2164"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.8.5379"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/9208035.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/9208035.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/9208035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T01:30:57Z","timestamp":1471570257000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2016\/9208035\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":24,"alternative-id":["9208035","9208035"],"URL":"https:\/\/doi.org\/10.1155\/2016\/9208035","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}