{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:15:15Z","timestamp":1787933715227,"version":"build-2784847793"},"reference-count":93,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T00:00:00Z","timestamp":1468454400000},"content-version":"vor","delay-in-days":195,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Cerebral white and grey matter injury is the leading cause of an adverse neurodevelopmental outcome in prematurely born infants. High oxygen concentrations have been shown to contribute to the pathogenesis of neonatal brain damage. Here, we focused on motor\u2010cognitive outcome up to the adolescent and adult age in an experimental model of preterm brain injury. In search of the putative mechanisms of action we evaluated oligodendrocyte degeneration, myelination, and modulation of synaptic plasticity\u2010related molecules. A single dose of erythropoietin (20,000\u2009IU\/kg) at the onset of hyperoxia (24 hours, 80% oxygen) in 6\u2010day\u2010old Wistar rats improved long\u2010lasting neurocognitive development up to the adolescent and adult stage. Analysis of white matter structures revealed a reduction of acute oligodendrocyte degeneration. However, erythropoietin did not influence hypomyelination occurring a few days after injury or long\u2010term microstructural white matter abnormalities detected in adult animals. Erythropoietin administration reverted hyperoxia\u2010induced reduction of neuronal plasticity\u2010related mRNA expression up to four months after injury. Thus, our findings highlight the importance of erythropoietin as a neuroregenerative treatment option in neonatal brain injury, leading to improved memory function in adolescent and adult rats which may be linked to increased neuronal network connectivity.<\/jats:p>","DOI":"10.1155\/2016\/9247493","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T17:58:51Z","timestamp":1468519131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Erythropoietin Restores Long\u2010Term Neurocognitive Function Involving Mechanisms of Neuronal Plasticity in a Model of Hyperoxia\u2010Induced Preterm Brain 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