{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:03:12Z","timestamp":1740164592715,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Cystatin C has been suggested to be a more accurate glomerular filtration rate (GFR) surrogate than creatinine in patients with acquired immunodeficiency syndrome (AIDS) because it is unaffected by skeletal muscle mass and dietary influences. However, little is known about the utility of this marker for monitoring medications in the critically ill. We describe the case of a 64-year-old female with opportunistic infections associated with a new diagnosis of AIDS. During her course, she experienced neurologic, cardiac, and respiratory failure; yet her renal function remained preserved as indicated by an eGFR \u2265 120\u2009mL\/min and a urine output &gt; 1\u2009mL\/kg\/hr without diuresis. The patient was treated with nephrotoxic agents; therefore cystatin C was assessed to determine if cachexia was resulting in a falsely low serum creatinine. Cystatin C measured 1.50\u2009mg\/L which corresponded to an eGFR of 36\u2009mL\/min. Given the &gt;60\u2009mL\/min discrepancy, serial 8-hour urine samples were collected and a GFR &gt; 120\u2009mL\/min was confirmed. It is unclear why cystatin C was falsely elevated, but we hypothesize that it relates to the proinflammatory state with AIDS, opportunistic infections, and corticosteroids. More research is needed before routine use of cystatin C in this setting can be recommended.<\/jats:p>","DOI":"10.1155\/2016\/9349280","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T21:03:53Z","timestamp":1463519033000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Cystatin C Falsely Underestimated GFR in a Critically Ill Patient with a New Diagnosis of AIDS"],"prefix":"10.1155","volume":"2016","author":[{"given":"Caitlin S.","family":"Brown","sequence":"first","affiliation":[{"name":"Hospital Pharmacy Services, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kianoush B.","family":"Kashani","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"},{"name":"Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy M.","family":"Clain","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0996-1487","authenticated-orcid":true,"given":"Erin N.","family":"Frazee","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy Services, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563215579695"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1114248"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1214234"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/mnh.0b013e32834b8850"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.638"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.03.027"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/cc3044"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.5812\/numonthly.15224"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328362e874"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000557"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5916.159282"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31823a6124"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/qai.0b013e31826a6c4f"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/cc13899"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.127373"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1515\/cclm.2010.318"},{"key":"17","first-page":"1","volume":"58","year":"2009","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1086\/589747"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2014.08.003"},{"issue":"2","key":"20","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/j.1875-9114.1993.tb02698.x","volume":"13","year":"1993","journal-title":"Pharmacotherapy"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu523"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082028"}],"container-title":["Case Reports in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2016\/9349280.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2016\/9349280.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2016\/9349280.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T12:14:09Z","timestamp":1718540049000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crin\/2016\/9349280\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":22,"alternative-id":["9349280","9349280"],"URL":"https:\/\/doi.org\/10.1155\/2016\/9349280","relation":{},"ISSN":["2090-6641","2090-665X"],"issn-type":[{"type":"print","value":"2090-6641"},{"type":"electronic","value":"2090-665X"}],"subject":[],"published":{"date-parts":[[2016]]}}}