{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T11:13:59Z","timestamp":1742382839062,"version":"3.37.3"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>We investigated the cardioprotective effect of renal ischemic postconditioning (RI-PostC) and its mechanisms in a rabbit model. Rabbits underwent 60\u2009min of left anterior descending coronary artery occlusion (LADO) and 6\u2009h of reperfusion. The ischemia-reperfusion (IR) group underwent LADO and reperfusion only. In the RI-PostC group, the left renal artery underwent 3 cycles of occlusion for 30 seconds and release for 30 seconds, before the coronary artery was reperfused. In the RI-PostC + GF109203X group, the rabbits received 0.05\u2009mg\/kg GF109203X (protein kinase C inhibitor) intravenously for 10\u2009min followed by RI-PostC. Light microscopy and electron microscopy demonstrated that the RI-PostC group showed less pronounced changes, a smaller infarct region, and less apoptosis than the other two groups. Bcl-2 and Bax protein expression did not differ between the IR and RI-PostC + GF109203X groups. However, in the RI-PostC group, Bcl-2 protein expression was significantly higher and Bax protein expression was significantly lower than in the other two groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). Changes in heart rate and mean arterial pressure were also smaller in the RI-PostC group than in the other two groups. These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2\/Bax ratio through a mechanism involving protein kinase C.<\/jats:p>","DOI":"10.1155\/2016\/9349437","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T16:10:18Z","timestamp":1482250218000},"page":"1-10","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Renal Ischemic Postconditioning on Myocardial Ultrastructural Organization and Myocardial Expression of Bcl-2\/Bax in Rabbits"],"prefix":"10.1155","volume":"2016","author":[{"given":"Wen-zhong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7993-6327","authenticated-orcid":true,"given":"Ji-dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-feng","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-lang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v7.i10.621"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62156-5"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.74.5.1124"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-005-0523-x"},{"key":"5","doi-asserted-by":"crossref","first-page":"H579","DOI":"10.1152\/ajpheart.01064.2002","volume":"285","year":"2003","journal-title":"American Journal of Physiology\u2014Heart and Circulatory Physiology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-11-1068"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3344"},{"issue":"5","key":"8","first-page":"77","volume":"77","year":"2005","journal-title":"Terapevticheskii Arkhiv"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2009.04.004"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.653782"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.05.011"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1159\/000418815"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.2.609"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e32835cecc6"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12181"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2459\/jcm.0b013e328357bff2"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5030"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2011.06.023"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-013-0366-6"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2009.00949.x"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-006-0292-5"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-005-0539-2"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5297"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu167"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.05.041"},{"issue":"20","key":"26","first-page":"1723","volume":"118","year":"2005","journal-title":"Chinese Medical Journal"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq129"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.1.350"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.02.014"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1648-0"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-010-0450-5"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)01109-X"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-010-9461-7"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000151290.04952.3B"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.755066"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.01.003"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu172"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1097\/01.crd.0000124914.59755.8d"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-006-0584-5"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.07.014"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-010-0104-5"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1413534"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1413579"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.06.325"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.3892\/br.2015.485"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.5935\/abc.20140181"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(03)00022-8"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00864.2005"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00055.2005"},{"issue":"6","key":"50","first-page":"68","volume":"50","year":"2010","journal-title":"Kardiologiya"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1159\/000437352"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft313"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12976"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.4172\/2329-9517.1000115"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2013(02)oa22"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00690.2015"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.116.307509"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0366-6999.2011.14.023"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/9349437.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/9349437.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/9349437.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T02:24:05Z","timestamp":1498357445000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2016\/9349437\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":58,"alternative-id":["9349437","9349437"],"URL":"https:\/\/doi.org\/10.1155\/2016\/9349437","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2016]]}}}