{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:38:10Z","timestamp":1769009890532,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Center","award":["N N407 598338"],"award-info":[{"award-number":["N N407 598338"]}]},{"name":"Medical University of Bialystok, Poland","award":["N N407 598338"],"award-info":[{"award-number":["N N407 598338"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Imbalance in the metabolites levels which can potentially be related to certain fetal chromosomal abnormalities can stimulate mother\u2019s immune response to produce autoantibodies directed against proteins. The aim of the study was to determine the concentration of 9000 autoantibodies in maternal plasma to detect fetal Down syndrome.<jats:italic>Method.<\/jats:italic>We performed 190 amniocenteses and found 10 patients with confirmed fetal Down syndrome (15th\u201318th weeks of gestation). For the purpose of our control we chose 11 women without confirmed chromosomal aberration. To assess the expression of autoantibodies in the blood plasma, we used a protein microarray, which allows for simultaneous determination of 9000 proteins per sample.<jats:italic>Results.<\/jats:italic>We revealed 213 statistically significant autoantibodies, whose expression decreased or increased in the study group with fetal Down syndrome. The second step was to create a classifier of Down syndrome pregnancy, which includes 14 antibodies. The predictive value of the classifier (specificity and sensitivity) is 100%, classification errors, 0%, cross-validation errors, 0%.<jats:italic>Conclusion.<\/jats:italic>Our findings suggest that the autoantibodies may play a role in the pathophysiology of Down syndrome pregnancy. Defining their potential as biochemical markers of Down syndrome pregnancy requires further investigation on larger group of patients.<\/jats:p>","DOI":"10.1155\/2016\/9362169","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T16:01:11Z","timestamp":1457280071000},"page":"1-11","source":"Crossref","is-referenced-by-count":6,"title":["Brief Communication: Maternal Plasma Autoantibodies Screening in Fetal Down Syndrome"],"prefix":"10.1155","volume":"2016","author":[{"given":"Karol","family":"Charkiewicz","sequence":"first","affiliation":[{"name":"Department of Perinatology and Obstetrics, Medical University of Bialystok, Marii Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Zbucka-Kretowska","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Marii Sklodowskiej-Curie 24a, 15-276 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