{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T06:16:15Z","timestamp":1775369775605,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000},"content-version":"vor","delay-in-days":265,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. To compare whether there is different effect between electroacupuncture (EA) and moxibustion (Mox) on visceral hypersensitivity (their analgesic effects) in constipation\u2010predominant irritable bowel syndrome (C\u2010IBS). <jats:italic>Methods<\/jats:italic>. EA at 1\u2009mA and 3\u2009mA and Mox at 43\u00b0C and 46\u00b0C were applied to the Shangjuxu (ST37, bilateral) acupoint in rats with C\u2010IBS and normal rats. An abdominal withdrawal reflex (AWR) score was used to assess visceral hypersensitivity. Toluidine blue staining was used to assess mast cell (MC) activity in colon of rats. Immunochemistry was used to measure 5\u2010HT and 5\u2010HT4 receptor expression in the colon. <jats:italic>Results<\/jats:italic>. AWR scores in all EA (1\u2009mA and 3\u2009mA) and Mox (43\u00b0C and 46\u00b0C) treatment groups after colorectal distention (CRD) stimulation pressure of 20, 40, 60, and 80\u2009mmHg were significantly lower than those of the model (MC) group (<jats:italic>P<\/jats:italic> all &lt; 0.01). The MC counts and degranulation rates in the colon of all EA and Mox treatment groups and the MC group were significantly higher than those of the NC group (<jats:italic>P<\/jats:italic> all &lt; 0.01). MC degranulation rates in the colon of all EA and Mox treatment groups were lower than those of the MC group (<jats:italic>P<\/jats:italic> all &lt; 0.05). 5\u2010HT expression in colon of all EA and Mox treatment groups was significantly lower than that of the MC group (<jats:italic>P<\/jats:italic> all &lt; 0.01), and 5\u2010HT4R expression in colon of both EA groups was significantly higher than that of the MC group (<jats:italic>P<\/jats:italic> both &lt; 0.01). <jats:italic>Conclusion<\/jats:italic>. EA and Mox treatments may both ameliorate visceral hypersensitivity at different degree in rats with C\u2010IBS, and EA treatment was better than Mox.<\/jats:p>","DOI":"10.1155\/2016\/9410505","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T21:31:14Z","timestamp":1474579874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of Electroacupuncture and Moxibustion for Relieving Visceral Hypersensitivity in Rats with Constipation\u2010Predominant Irritable Bowel Syndrome"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9075-6036","authenticated-orcid":false,"given":"Ji-Meng","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3853-6612","authenticated-orcid":false,"given":"Liu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1636-4231","authenticated-orcid":false,"given":"Ci-Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7502-1573","authenticated-orcid":false,"given":"Yin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7795-6698","authenticated-orcid":false,"given":"Yu-Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8821-3585","authenticated-orcid":false,"given":"Hai-Xia","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8888-1698","authenticated-orcid":false,"given":"Lu-Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-0046","authenticated-orcid":false,"given":"Chun-Hui","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan-Zi","family":"Dou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1725-6881","authenticated-orcid":false,"given":"Huan-Gan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,22]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2012.756397"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1005502119461"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.018911"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9270(01)02515-1"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.4318\/tjg.2011.0212"},{"key":"e_1_2_7_6_2","first-page":"646","article-title":"SCF and 5-HT in irritable bowel syndrome patients in the intestinal mucosa of the expression and significance","volume":"4","author":"Yang J.","year":"2015","journal-title":"Jilin Medical Journal"},{"key":"e_1_2_7_7_2","first-page":"453","article-title":"Are symptomatic changes in irritable bowel syndrome correlated with the capsule endoscopy transit time? A pilot study using the 5-HT4 receptor agonist mosapride","volume":"58","author":"Nakamura M.","year":"2011","journal-title":"Hepato-Gastroenterology"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00685.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01867.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(15)30116-3"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0863-5"},{"key":"e_1_2_7_12_2","first-page":"913","article-title":"A new acupuncture method for management of irritable bowel syndrome: a randomized double blind clinical trial","volume":"19","author":"Rafiei R.","year":"2014","journal-title":"Journal of Research in Medical Sciences"},{"key":"e_1_2_7_13_2","volume-title":"The Scientific Basis of Acupuncture","author":"Zhu B.","year":"1998"},{"key":"e_1_2_7_14_2","first-page":"112","article-title":"Constipation irritable bowel to establish a comprehensive new model of syndrome","volume":"12","author":"Peng L. H.","year":"2004","journal-title":"World Journal of Gastroenterology"},{"key":"e_1_2_7_15_2","volume-title":"Experimental Acupuncture","author":"Li Z. R.","year":"2007"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.19576"},{"key":"e_1_2_7_17_2","first-page":"35","article-title":"Constipation bowel to bowel syndrome of 5-HT in rat intestinal tissue of experimental study","volume":"30","author":"Yang Q.","year":"2014","journal-title":"Chinese Journal of Clinical Research"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/meg.0b013e32832e9d6b"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i16.4852"},{"key":"e_1_2_7_20_2","first-page":"1228","article-title":"Effect of Changan Decoction No.1 on irritable 5-HT signaling system in visceral hypersensitivity rats and hippocampal BDNF mRNA expression of bowel syndrome","volume":"10","author":"Zhao Y. P.","year":"2015","journal-title":"Chinese Journal of Integrative Medicine"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04153.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1145-09.2009"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2012007500122"},{"key":"e_1_2_7_24_2","first-page":"371","article-title":"Role of serotonin in the pathophysiology of the irritable bowel syndrome","volume":"60","author":"Moskwa A.","year":"2007","journal-title":"Wiadomo\u015bci Lekarskie"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000228975.87645.27"},{"key":"e_1_2_7_26_2","volume-title":"Irritable Bowel Syndrome","author":"Li Y. Q.","year":"2005"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705762"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000190"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0376-2491.2013.38.016"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i20.6044"},{"key":"e_1_2_7_31_2","first-page":"478","article-title":"Relationship between laser acupuncture analgesia and the function of mast cells","volume":"29","author":"Cheng K.","year":"2009","journal-title":"Chinese Acupuncture & Moxibustion"},{"key":"e_1_2_7_32_2","first-page":"2266","article-title":"Effect of umbilical therapy on irritable bowel syndrome of spleen deficiency type of serum ghrelin level of patients","volume":"26","author":"Yang X. M.","year":"2011","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"key":"e_1_2_7_33_2","first-page":"82","article-title":"Discussion on the construction of acupuncture effect to start a small network of mast cell-derived exosomes","volume":"40","author":"Chen B.","year":"2015","journal-title":"Acupuncture Research"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.213108"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf01308592"},{"key":"e_1_2_7_36_2","first-page":"332","article-title":"Irritable bowel syndrome patients associated with intestinal mucosal mast cells and nerve fibers","volume":"23","author":"Wang L. H.","year":"2003","journal-title":"Chinese Journal of Digestion"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0062-4"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/9410505.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/9410505.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/9410505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T01:13:49Z","timestamp":1722906829000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/9410505"}},"subtitle":[],"editor":[{"given":"Hyunsu","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/9410505"],"URL":"https:\/\/doi.org\/10.1155\/2016\/9410505","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2016-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9410505"}}