{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:22:13Z","timestamp":1770834133860,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["YCSA 113380"],"award-info":[{"award-number":["YCSA 113380"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["CIA 130020"],"award-info":[{"award-number":["CIA 130020"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["CIA 103027"],"award-info":[{"award-number":["CIA 103027"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["130033"],"award-info":[{"award-number":["130033"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["5R01HL098528-05"],"award-info":[{"award-number":["5R01HL098528-05"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["R01 HL086936-07"],"award-info":[{"award-number":["R01 HL086936-07"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["YCSA 113380"],"award-info":[{"award-number":["YCSA 113380"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["CIA 130020"],"award-info":[{"award-number":["CIA 130020"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["CIA 103027"],"award-info":[{"award-number":["CIA 103027"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["130033"],"award-info":[{"award-number":["130033"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["5R01HL098528-05"],"award-info":[{"award-number":["5R01HL098528-05"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["R01 HL086936-07"],"award-info":[{"award-number":["R01 HL086936-07"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["YCSA 113380"],"award-info":[{"award-number":["YCSA 113380"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["CIA 130020"],"award-info":[{"award-number":["CIA 130020"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["CIA 103027"],"award-info":[{"award-number":["CIA 103027"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["130033"],"award-info":[{"award-number":["130033"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["5R01HL098528-05"],"award-info":[{"award-number":["5R01HL098528-05"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["R01 HL086936-07"],"award-info":[{"award-number":["R01 HL086936-07"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["YCSA 113380"],"award-info":[{"award-number":["YCSA 113380"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["CIA 130020"],"award-info":[{"award-number":["CIA 130020"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["CIA 103027"],"award-info":[{"award-number":["CIA 103027"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["130033"],"award-info":[{"award-number":["130033"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["5R01HL098528-05"],"award-info":[{"award-number":["5R01HL098528-05"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","award":["R01 HL086936-07"],"award-info":[{"award-number":["R01 HL086936-07"]}],"id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["YCSA 113380"],"award-info":[{"award-number":["YCSA 113380"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CIA 130020"],"award-info":[{"award-number":["CIA 130020"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CIA 103027"],"award-info":[{"award-number":["CIA 103027"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["130033"],"award-info":[{"award-number":["130033"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01HL098528-05"],"award-info":[{"award-number":["5R01HL098528-05"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL086936-07"],"award-info":[{"award-number":["R01 HL086936-07"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["YCSA 113380"],"award-info":[{"award-number":["YCSA 113380"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CIA 130020"],"award-info":[{"award-number":["CIA 130020"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CIA 103027"],"award-info":[{"award-number":["CIA 103027"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["130033"],"award-info":[{"award-number":["130033"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01HL098528-05"],"award-info":[{"award-number":["5R01HL098528-05"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL086936-07"],"award-info":[{"award-number":["R01 HL086936-07"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Oxidative stress provokes endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) in the lungs of chronic obstructive pulmonary (COPD) subjects. The antioxidant, glutathione peroxidase-1 (GPx-1), counters oxidative stress induced by cigarette smoke exposure. Here, we investigate whether GPx-1 expression deters the UPR following exposure to cigarette smoke. Expression of ER stress markers was investigated in fully differentiated normal human bronchial epithelial (NHBE) cells isolated from nonsmoking, smoking, and COPD donors and redifferentiated at the air liquid interface. NHBE cells from COPD donors expressed heightened ATF4, XBP1, GRP78, GRP94, EDEM1, and CHOP compared to cells from nonsmoking donors. These changes coincided with reduced GPx-1 expression. Reintroduction of GPx-1 into NHBE cells isolated from COPD donors reduced the UPR. To determine whether the loss of GPx-1 expression has a direct impact on these ER stress markers during smoke exposure,<jats:italic>Gpx<\/jats:italic>-<jats:italic>1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>mice were exposed to cigarette smoke for 1 year. Loss of<jats:italic>Gpx<\/jats:italic>-<jats:italic>1<\/jats:italic>expression enhanced cigarette smoke-induced ER stress and apoptosis. Equally, induction of ER stress with tunicamycin enhanced antioxidant expression in mouse precision-cut lung slices. Smoke inhalation also exacerbated the UPR response during respiratory syncytial virus infection. Therefore, ER stress may be an antioxidant-related pathophysiological event in COPD.<\/jats:p>","DOI":"10.1155\/2016\/9461289","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T16:01:47Z","timestamp":1481644907000},"page":"1-16","source":"Crossref","is-referenced-by-count":29,"title":["Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1647-5505","authenticated-orcid":true,"given":"Patrick","family":"Geraghty","sequence":"first","affiliation":[{"name":"Division of Pulmonary & Critical Care Medicine, Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, USA"},{"name":"Department of Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Baumlin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Miami, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias A.","family":"Salathe","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Miami, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3964-5335","authenticated-orcid":true,"given":"Robert F.","family":"Foronjy","sequence":"additional","affiliation":[{"name":"Division of Pulmonary & Critical Care Medicine, Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, USA"},{"name":"Department of Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanine M.","family":"D\u2019Armiento","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Disease, Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","first-page":"1","volume-title":"Deaths: final data for 2013","year":"2016"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-850OC"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.04.014"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m114.603738"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2147\/copd.s19599"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.12.009"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-229"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0221oc"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.03.003"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.10.1211"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209038"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.23.21.7448-7459.2003"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0026oc"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00598.2001"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2003.10.020"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.664250"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00038.2010"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2002-0012OC"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr351"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00073.2016"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00004206"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702394"},{"key":"23","first-page":"39","volume":"19","year":"2013","journal-title":"Molecular Vision"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.10.2108049a"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200504-025sr"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.510594"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00077604"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-03-2272"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2006.06.006"},{"issue":"7","key":"30","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1093\/jn\/128.7.1070","volume":"128","year":"1998","journal-title":"Journal of Nutrition"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.04.038"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1089\/15230860152409068"},{"issue":"8","key":"33","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1093\/jn\/127.8.1445","volume":"127","year":"1997","journal-title":"Journal of Nutrition"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0325OC"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.400"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093472"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(73)80755-0"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1021"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000164401.21929.CF"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.19.1.1"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20020625"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501452200"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200421146"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2005.00905.x"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.10.6968"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211558200"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.20.7198-7209.2003"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.14"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.11.3787"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.3.684"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1038\/nm1238"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.138"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.111"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201405-0872OC"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-4889(03)00029-6"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.01.004"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040801"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00487.2011"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2016\/9461289.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2016\/9461289.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2016\/9461289.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T09:45:27Z","timestamp":1568627127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2016\/9461289\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":58,"alternative-id":["9461289","9461289"],"URL":"https:\/\/doi.org\/10.1155\/2016\/9461289","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}