{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:56:49Z","timestamp":1778731009850,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Commission of Shanghai","award":["13DJ1400303"],"award-info":[{"award-number":["13DJ1400303"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>The thalamus and hippocampus have been found both involved in the initiation, propagation, and termination of temporal lobe epilepsy. However, the interaction of these regions during seizures is not clear. The present study is to explore whether some regular patterns exist in their interaction during the termination of seizures. Multichannel in vivo recording techniques were used to record the neural activities from the cornu ammonis 1 (CA1) of hippocampus and mediodorsal thalamus (MDT) in mice. The mice were kindled by electrically stimulating basolateral amygdala neurons, and Racine\u2019s rank standard was employed to classify the stage of behavioral responses (stage 1~5). The coupling index and directionality index were used to investigate the synchronization and information flow direction between CA1 and MDT. Two main results were found in this study.<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mn fontstyle=\"italic\">1<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>High levels of synchronization between the thalamus and hippocampus were observed before the termination of seizures at stage 4~5 but after the termination of seizures at stage 1~2.<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mn fontstyle=\"italic\">2<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>In the end of seizures at stage 4~5, the information tended to flow from MDT to CA1. Those results indicate that the synchronization and information flow direction between the thalamus and the hippocampus may participate in the termination of seizures.<\/jats:p>","DOI":"10.1155\/2016\/9580724","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T21:07:40Z","timestamp":1476738460000},"page":"1-10","source":"Crossref","is-referenced-by-count":4,"title":["Interaction between Thalamus and Hippocampus in Termination of Amygdala-Kindled Seizures in Mice"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4207-9728","authenticated-orcid":true,"given":"Zhen","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China"}]},{"given":"Jia-Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0768-3030","authenticated-orcid":true,"given":"Qin-Chi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5007-5076","authenticated-orcid":true,"given":"Hai-Qing","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3599-5306","authenticated-orcid":true,"given":"Pei-Ji","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1384-2376","authenticated-orcid":true,"given":"Pu-Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.01.028"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02522.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.07.012"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.5698\/1535-7511-12.5.203"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1292-0"},{"key":"6","year":"2006"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/637430"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01144.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.042008967.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2009.2023291"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/675128"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000206364.19772.39"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01408.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1103\/physreve.69.066138"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.4250-04.2005"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/pl00007990"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0020144"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.09.006"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2014.06.004"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2005.06.011"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.05.071"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1103\/physreve.77.026214"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1103\/physrevlett.100.084101"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.05.003"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2014.02.006"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153897"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(72)90177-0"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.09.033"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/s1388-2457(02)00197-9"},{"issue":"17","key":"30","volume":"88","year":"2002","journal-title":"Physical Review Letters"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-013-0594-7"},{"issue":"2","key":"32","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1750-3639.2002.tb00439.x","volume":"12","year":"2002","journal-title":"Brain Pathology"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl304"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092961"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.04.017"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.10.025"},{"key":"37","year":"2002"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.06.006"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl151"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1109\/tbme.2012.2189113"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.239590"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-013-0284-z"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13259"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.08.051"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/13.8.883"},{"issue":"5","key":"47","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1152\/jn.1994.72.5.2051","volume":"72","year":"1994","journal-title":"Journal of Neurophysiology"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00368.2010"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2782"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12916"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2005.30304.x"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-4886(03)00045-1"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2015.11.009"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2007.09.010"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.08.007"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.11.014"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00192"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2016\/9580724.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2016\/9580724.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2016\/9580724.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:18:10Z","timestamp":1718842690000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2016\/9580724\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":56,"alternative-id":["9580724","9580724"],"URL":"https:\/\/doi.org\/10.1155\/2016\/9580724","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}