{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:26:42Z","timestamp":1759336002009,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Objective electrophysiological methods for investigations of the organ of smell consist in recordings of olfactory cortex responses to specific, time restricted odor stimuli. In hypothyroidism have impaired sense of smell.<jats:italic>Material and Methods<\/jats:italic>. Two groups: control of 31 healthy subjects and study group of 21 with hypothyroidism. The inclusion criterion for the study group was the TSH range from 3.54 to 110\u2009<jats:italic>\u03bc<\/jats:italic>IU\/mL.<jats:italic>Aim<\/jats:italic>. Assessment of the latency time of evoked responses from the olfactory nerve N1 and the trigeminal nerve N5 using two smells of mint and anise in hypothyroidism.<jats:italic>Results<\/jats:italic>. The smell perception in subjective olfactory tests was normal in 85% of the hypothyroid group. Differences were noticed in the objective tests. The detailed intergroup analysis of latency times of recorded cortical responses<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">N<\/mml:mi><mml:mn mathvariant=\"normal\">5<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">N<\/mml:mi><mml:mn mathvariant=\"normal\">1<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>performed by means between the groups of patients with overt clinical hypothyroidism versus subclinical hypothyroidism demonstrated a significant difference (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>) whereas no such differences were found between the control group versus subclinical hypothyroidism group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. We can conclude that registration of cortex potentials at irritation of olfactory and trigeminal nerves offers possibilities for using this method as an objective indicator of hypothyroidism severity and prognostic process factor.<\/jats:p>","DOI":"10.1155\/2016\/9583495","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T18:28:13Z","timestamp":1472581693000},"page":"1-7","source":"Crossref","is-referenced-by-count":10,"title":["Hypothyroidism Affects Olfactory Evoked Potentials"],"prefix":"10.1155","volume":"2016","author":[{"given":"Teodor","family":"\u015awidzi\u0144ski","sequence":"first","affiliation":[{"name":"Department of Biophysics, ul. Fredry 10, 61-701 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1734-4865","authenticated-orcid":true,"given":"Kamila","family":"Linkowska-\u015awidzi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology, University of Medical Sciences, ul. Bukowska 70, 60-567 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Czerniejewska-Wolska","sequence":"additional","affiliation":[{"name":"Department of Phoniatrics and Audiology, University of Medical Sciences, ul. Przybyszewskiego 49, 60-355 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u017cena","family":"Wiskirska-Wo\u017anica","sequence":"additional","affiliation":[{"name":"Department of Phoniatrics and Audiology, University of Medical Sciences, ul. Przybyszewskiego 49, 60-355 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Owecki","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences, ul. Przybyszewskiego 49, 60-355 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Danuta","family":"G\u0142owacka","sequence":"additional","affiliation":[{"name":"Department of Organization and Management in Health Care, University of Medical Sciences, ul. Smoluchowskiego 11, 60-179 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Frankowska","sequence":"additional","affiliation":[{"name":"Department of Organization and Management in Health Care, University of Medical Sciences, ul. 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