{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:56:46Z","timestamp":1785549406977,"version":"3.56.0"},"reference-count":70,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["PN-II-PT-PCCA-2013-4-1407"],"award-info":[{"award-number":["PN-II-PT-PCCA-2013-4-1407"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["PNII-PT-PCCA-2013-4-1386"],"award-info":[{"award-number":["PNII-PT-PCCA-2013-4-1386"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["PN-II-PT-PCCA-2013-4-1407"],"award-info":[{"award-number":["PN-II-PT-PCCA-2013-4-1407"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["PNII-PT-PCCA-2013-4-1386"],"award-info":[{"award-number":["PNII-PT-PCCA-2013-4-1386"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Cutaneous T-cell lymphoma (CTCL) is the most frequently encountered type of skin lymphoma in humans. CTCL encompasses multiple variants, but the most common types are mycosis fungoides (MF) and Sezary syndrome (SS). While most cases of MF run a mild course over a period of many years, other subtypes of CTCL are very aggressive. The rapidly expanding fields of proteomics and genomics have not only helped increase knowledge concerning the carcinogenesis and tumor biology of CTCL but also led to the discovery of novel markers for targeted therapy. Although multiple biomarkers linked to CTCL have been known for a relatively long time (e.g., CD25, CD45, CD45RA, and CD45R0), compared to other cancers (lymphoma, melanoma, colon carcinoma, head and neck cancer, renal cancer, and cutaneous B-cell lymphoma), information about the antigenicity of CTCL remains relatively limited and no dependable protein marker for CTCL has been discovered. Considering the aggressive nature of some types of CTCL, it is necessary to identify circulating molecules that can help in the early diagnosis, differentiation from inflammatory skin diseases (psoriasis, nummular eczema), and aid in predicting the prognosis and evolution of this pathology. This review aims to bring together some of the information concerning protein markers linked to CTCL, in an effort to further the understanding of the convolute processes involved in this complex pathology.<\/jats:p>","DOI":"10.1155\/2016\/9602472","type":"journal-article","created":{"date-parts":[[2016,10,16]],"date-time":"2016-10-16T21:02:37Z","timestamp":1476651757000},"page":"1-8","source":"Crossref","is-referenced-by-count":22,"title":["Proteomic Approaches to Biomarker Discovery in Cutaneous T-Cell Lymphoma"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1749-4102","authenticated-orcid":true,"given":"Alexandra","family":"Ion","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7702-448X","authenticated-orcid":true,"given":"Iris Maria","family":"Popa","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, \u201cBagdasar Arseni\u201d Clinical Emergency Hospital, 041915 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Maria Lucia","family":"Papagheorghe","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Lisievici","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-0817","authenticated-orcid":true,"given":"Mihai","family":"Lupu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5671-9378","authenticated-orcid":true,"given":"Vlad","family":"Voiculescu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-7965","authenticated-orcid":true,"given":"Constantin","family":"Caruntu","sequence":"additional","affiliation":[{"name":"Department of Physiology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Dermatology, \u201cProf. N. C. Paulescu\u201d National Institute of Diabetes, Nutrition and Metabolic Diseases, 020475 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3282-3426","authenticated-orcid":true,"given":"Daniel","family":"Boda","sequence":"additional","affiliation":[{"name":"Dermatology Research Laboratory, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Dermatology, Carol Medical Center, 020915 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.729831"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.118538"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.45"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.4683"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13583"},{"issue":"3","key":"7","first-page":"73","volume":"8","year":"2011","journal-title":"Internal Medicine-Medicina Interna"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4517492"},{"issue":"1","key":"9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2174\/2210310411101010010","volume":"1","year":"2011","journal-title":"Recent Patents on Biomarkers"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2174\/1570164611310030003"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9831237"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.14.76"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.15190\/d.2015.30"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-394383-5.00011-4"},{"issue":"6","key":"15","first-page":"365","volume":"143","year":"2008","journal-title":"Giornale Italiano di Dermatologia e Venereologia"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2008.07.014"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2006.05982.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(98)70597-3"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1159\/000080852"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1593\/neo.06805"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-061507"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-005-0699-9"},{"issue":"3","key":"23","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","volume":"155","year":"1995","journal-title":"The Journal of Immunology"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/nature05673"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041982"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1038\/ni1437"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.10.5986"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008376"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2350"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-181024"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.192"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04340.x"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20431"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404350"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/97.1.121"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00830.x"},{"issue":"4","key":"37","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1182\/blood.V90.4.1636.1636_1636_1642","volume":"90","year":"1997","journal-title":"Blood"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.124696"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08185.x"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201000165"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747"},{"issue":"4","key":"42","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/clinchem\/39.4.561","volume":"39","year":"1993","journal-title":"Clinical Chemistry"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.08.026"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2005.03.006"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.07.014"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.01.022"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.10.4372"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10296"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1177\/002215540305100513"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1021\/bi990305u"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.461"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-014-1501-7"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.5603\/fhc.2011.0033"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2001.tb00015.x"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.2174\/157016307781115467"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3574"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021726"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2813"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1126\/science.2432664"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1038\/nm0195-27"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.3.233"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1038\/35025215"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2002.00061.x"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.05.005"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1633"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12490"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701013"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-460535"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2012.01883.x"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01489.x"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/9602472.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/9602472.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/9602472.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T23:44:11Z","timestamp":1718840651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2016\/9602472\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":70,"alternative-id":["9602472","9602472"],"URL":"https:\/\/doi.org\/10.1155\/2016\/9602472","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}