{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:02:03Z","timestamp":1770447723456,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T00:00:00Z","timestamp":1464652800000},"content-version":"vor","delay-in-days":151,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Hypercholesterolemia is a well\u2010known etiological factor for cardiovascular disease and a common symptom of most types of metabolic disorders. <jats:italic>Camellia japonica<\/jats:italic> is a traditional garden plant, and its flower and seed have been used as a base oil of traditional cosmetics in East Asia. The present study was carried out to evaluate the effect of <jats:italic>C. japonica<\/jats:italic> fruit extracts (CJF) in a high fat diet\u2010 (HFD\u2010) induced hypercholesterolemic rat model. CJF was administered orally at three different doses: 100, 400, and 800\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup> (CJF 100, 400, and 800, resp.). Our results showed that CJF possessed strong cholesterol\u2010lowering potency as indicated by the decrease in serum total cholesterol (TC), triglyceride (TG), and low\u2010density lipoprotein (LDL), accompanied by an increase in serum high\u2010density lipoprotein (HDL). Furthermore, CJF reduced serum lipid peroxidation by suppressing the formation of thiobarbituric acid reactive substance. In addition, oil red O (ORO) staining of rat arteries showed decreased lipid\u2010positive staining in the CJF\u2010treated groups compared to the control HFD group. Taken together, these results suggest that CJF could be a potent herbal therapeutic option and source of a functional food for the prevention and treatment of atherosclerosis and other diseases associated with hypercholesterolemia.<\/jats:p>","DOI":"10.1155\/2016\/9679867","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T21:04:31Z","timestamp":1464728671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Antiatherogenic Effect of <i>Camellia japonica<\/i> Fruit Extract in High Fat Diet\u2010Fed Rats"],"prefix":"10.1155","volume":"2016","author":[{"given":"Hyun-Ho","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keshav Raj","family":"Paudel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieun","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-Jin","family":"Wi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whoa-Shig","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Wook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5584-1702","authenticated-orcid":false,"given":"Min-Ho","family":"Oak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,31]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1672"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1987.03390160062027"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0126"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x15500421"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.14769"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2438"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118393"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3863726"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.05.009"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/962025"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.03.020"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/502182"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.2307\/2443568"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.919"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2003.07.003"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12395"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf400938h"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6309565"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000131513.33892.5b"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_2_7_22_2","first-page":"582","article-title":"Investigation of antioxidant and anti-inflammatory activity of roots of Rumex nepalensis","volume":"4","author":"Devkota S. 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