{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T23:41:40Z","timestamp":1724370100122},"reference-count":19,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Thyroid Research"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>There is continuing debate on the optimal treatment for Grave\u2019s thyrotoxicosis with a resultant variation in clinical practice. The present study aimed to ascertain changes in practice in the treatment of Grave\u2019s thyrotoxicosis in Tayside, Scotland, over the past four decades.<jats:italic>Methods<\/jats:italic>. The \u201cScottish automated follow-up register\u201d (SAFUR) was queried to identify all patients treated for Grave\u2019s thyrotoxicosis from 1968 to 2007 inclusive. Patients were divided into 4 groups (Groups A to D) according to the decades. Demographic profile, treatment modalities, radioactive iodine (RAI) dose, and recurrence rates were studied and outcomes were compared by<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msup><mml:mrow><mml:mi>\u03c7<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">2<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>test and ANOVA using SPSS v15.0. A<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>p<\/mml:mi><\/mml:mrow><\/mml:math>value of &lt; 0.05 was considered significant.<jats:italic>Results<\/jats:italic>. Altogether, 3737 patients were diagnosed with Grave\u2019s thyrotoxicosis over the 4 decades. Use of RAI has increased from 43.1% in Group A to 68% in Group D (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). The dose of RAI has increased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) and there has been a reduction in recurrence rate with higher dose of RAI. Surgical intervention rates decreased from 55.3% to 12.3% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) over time.<jats:italic>Conclusions<\/jats:italic>. Analysis of a large dataset of patients with Grave\u2019s thyrotoxicosis suggests increasing use of RAI as the preferred first line of treatment. Furthermore, using a single higher dose of RAI and adoption of total thyroidectomy have decreased recurrence rates.<\/jats:p>","DOI":"10.1155\/2016\/9697849","type":"journal-article","created":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T21:02:12Z","timestamp":1464642132000},"page":"1-6","source":"Crossref","is-referenced-by-count":7,"title":["Change in Practice over Four Decades in the Management of Graves\u2019 Disease in Scotland"],"prefix":"10.1155","volume":"2016","author":[{"given":"D. M.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Surgery, Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dutta","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow G31 2ER, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"School of Medicine, Guy\u2019s King\u2019s & St. Thomas\u2019 Hospitals, King\u2019s College London, London SE1 1UL, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Thaha","sequence":"additional","affiliation":[{"name":"Academic Surgical Unit, Blizard Institute, National Centre for Bowel Research & Surgical Innovation, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London E1 1BB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcp0801880"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200010263431707"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0950-351x(97)80798-7"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2011.10.010"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1991.1.129"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.8.2986"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2006.09.007"},{"issue":"5695","key":"8","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1136\/bmj.1.5695.556","volume":"1","year":"1970","journal-title":"British Medical Journal"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2011.01.029"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2009.03.025"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2004.14.933"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0153"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030185"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-105-6-900"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1995.tb01547.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020805"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.3.1073"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6441.361"},{"key":"19","first-page":"S21","volume":"23","year":"2015","journal-title":"International Journal of Surgery"}],"container-title":["Journal of Thyroid Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtr\/2016\/9697849.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtr\/2016\/9697849.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtr\/2016\/9697849.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T15:21:40Z","timestamp":1498317700000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jtr\/2016\/9697849\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":19,"alternative-id":["9697849","9697849"],"URL":"https:\/\/doi.org\/10.1155\/2016\/9697849","relation":{},"ISSN":["2090-8067","2042-0072"],"issn-type":[{"value":"2090-8067","type":"print"},{"value":"2042-0072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}