{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:36:45Z","timestamp":1771951005252,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T00:00:00Z","timestamp":1472428800000},"content-version":"vor","delay-in-days":241,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chengdu Military Region\u2019s 12th Five Year Foundation","award":["C12053"],"award-info":[{"award-number":["C12053"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Hindlimb ischemia is still a clinical problem with high morbidity and mortality. Patients suffer from consequent rest pain, ulcers, cool limbs, and even amputation. Angiogenesis is a promising target for the treatment of ischemic limbs, providing extra blood for the ischemic region. In the present study, we investigated the role of umbilical cord\u2010derived mesenchymal stem cells (UC\u2010MSCs) in regulating angiogenesis and relieving hindlimb ischemia. UC\u2010MSCs were isolated from the umbilical cord of tree shrews. Angiography results showed that UC\u2010MSCs injection significantly promoted angiogenesis in tree shrews. Moreover, the ankle brachial index, transcutaneous oxygen pressure, blood perfusion, and capillary\/muscle fiber ratio were all markedly increased by the application of UC\u2010MSCs. In addition, the conditioned culture of human umbilical vein endothelial cells using medium collected from UC\u2010MSCs showed higher expression of angiogenic markers and improved migration ability. In short, the isolated UC\u2010MSCs notably contributed to restoring blood supply and alleviating the symptoms of limb ischemia through enhancing angiogenesis.<\/jats:p>","DOI":"10.1155\/2016\/9742034","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T21:05:21Z","timestamp":1472504721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Umbilical Cord\u2010Derived Mesenchymal Stem Cells Relieve Hindlimb Ischemia through Enhancing Angiogenesis in Tree 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