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<jats:italic>Results.<\/jats:italic> Eight RCTs including 643 RA patients were included in the present meta\u2010analysis. The quality of included studies was poor. The levels of ESR (<jats:italic>P<\/jats:italic> &lt; 0.0001), CRP (<jats:italic>P<\/jats:italic> &lt; 0.0001), and RF (<jats:italic>P<\/jats:italic> &lt; 0.0001) in RA patients who received the combination of TGP and LEF were significantly lower than RA patients who received LEF therapy alone. The pooled results suggest that the combination of TGP and LEF caused less abnormal liver function than LEF alone (<jats:italic>P<\/jats:italic> = 0.02). No significant difference in the gastrointestinal discomfort was identified between the combination of TGP and LEF and LEF alone groups (<jats:italic>P<\/jats:italic> = 0.18). <jats:italic>Conclusion.<\/jats:italic> The combination of TGP and LEF in treatment of RA presented the characteristics of notably decreasing the levels of laboratory indexes and higher safety in terms of liver function. However, this conclusion should be further investigated based on a larger sample size.<\/jats:p>","DOI":"10.1155\/2016\/9852793","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T21:01:32Z","timestamp":1460322092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Efficacy and Safety of the Combination of Total Glucosides of Peony and Leflunomide for the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2016","author":[{"given":"Zhitao","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guochao","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiqun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liguo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengzhi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,10]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-015-9477-2"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-15-376"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200422001-00002"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1004965"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21298"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2015.02.001"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21641"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204573"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(04)16676-2"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar3060"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.11.012"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-007-7190-3"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-007-7240-x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.06.001"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.02.002"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.1131"},{"key":"e_1_2_9_17_2","volume-title":"Drug Therapy for Rheumatoid Arthritis in Adults: An Update","author":"Donahue K. 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