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Although IL-33 expression can be altered upon NF-Kappa B activation, here we examine regulation by Oncostatin M, a gp130 cytokine family member, in mouse lung tissue. Responses were assessed in BALB\/c mouse lung at day 7 of transient overexpression using endotracheally administered adenovirus encoding OSM (AdOSM) or empty vector (AdDel70). Whole lung extracts showed induction of IL-33 mRNA (&gt;20-fold) and protein (10-fold increase in immunoblots) by AdOSM relative to AdDel70. Immunohistochemistry for IL-33 indicated a marked induction of nuclear staining in alveolar epithelial cells<jats:italic>in vivo<\/jats:italic>. Oncostatin M stimulated IL-33 mRNA and IL-33 full length protein in C10 mouse type 2 alveolar epithelial cells in culture in time-dependent and dose-dependent fashion, whereas IL-6, LIF, IL-31, IL-4, or IL-13 did not, and TGF<jats:italic>\u03b2<\/jats:italic>repressed IL-33. IL-33 induction was associated with activation of STAT3, and pharmacological inhibition of STAT3 ameliorated IL-33 levels. These results indicate Oncostatin M as a potent inducer of IL-33 in mouse lung epithelial cells and suggest that an OSM\/IL-33 axis may participate in innate immunity and inflammatory conditions in lung.<\/jats:p>","DOI":"10.1155\/2016\/9858374","type":"journal-article","created":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T17:09:57Z","timestamp":1473959397000},"page":"1-12","source":"Crossref","is-referenced-by-count":21,"title":["Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0081-2231","authenticated-orcid":true,"given":"Carl D.","family":"Richards","sequence":"first","affiliation":[{"name":"McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Izakelian","sequence":"additional","affiliation":[{"name":"McMaster 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