{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:47:48Z","timestamp":1762102068991,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"International Cooperation Foundation of Henan Science and Technology Research","award":["172102410021"],"award-info":[{"award-number":["172102410021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. This study aims to explore the efficacy of tumor-infiltrating lymphocytes (TIL) along with interferon-<jats:italic>\u03b1<\/jats:italic> (IFN-<jats:italic>\u03b1<\/jats:italic>) to treat stage III malignant melanoma (MM) patients in China. <jats:italic>Methods<\/jats:italic>. Between May 2010 and October 2014, 77 patients of stage III MM who underwent surgery were collected in this study. These patients were divided into two groups: patients who received TIL\u2009+\u2009IFN-<jats:italic>\u03b1<\/jats:italic>\u2009\u00b1\u2009RetroNectin-activated cytokine-induced killer cells (R-CIK) in Arm 1 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>27<\/mml:mn><\/mml:math>) and IFN-<jats:italic>\u03b1<\/jats:italic>\u2009\u00b1\u2009R-CIK in Arm 2 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>50<\/mml:mn><\/mml:math>) as adjuvant therapy. The primary endpoints were disease-free survival (DFS) time and DFS rates measured at time points of 1, 2, and 3 years. The secondary endpoints were overall survival (OS) rates measured at time points of 1, 2, 3, and 5 years as well as OS as evaluated by Kaplan-Meier. <jats:italic>Results<\/jats:italic>. Our results indicated that the median DFS and OS in Arm 1 were significantly better than those in Arm 2. The data also demonstrated that DFS rate and OS rates in Arm 1 were significantly better than those in Arm 2 at all measured time points. <jats:italic>Conclusion<\/jats:italic>. Patients who undergo surgical excision of stage III MM appear to enjoy prolonged DFS and OS when treated with TIL\u2009+\u2009IFN-<jats:italic>\u03b1<\/jats:italic> compared to IFN-<jats:italic>\u03b1<\/jats:italic> alone.<\/jats:p>","DOI":"10.1155\/2017\/1092507","type":"journal-article","created":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T17:02:17Z","timestamp":1503248537000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of Tumor-Infiltrating Lymphocytes Combined with IFN-<i>\u03b1<\/i> in Chinese Resected Stage III Malignant Melanoma"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5550-508X","authenticated-orcid":true,"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, China"},{"name":"School of Life Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Research and Foreign Affairs, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaomei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingdi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel B.","family":"Kellner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Weill Cornell Medical College, New 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