{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:44:13Z","timestamp":1759160653365,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","award":["UM.C\/625\/1\/HIR\/MOHE\/MED\/25","E0063"],"award-info":[{"award-number":["UM.C\/625\/1\/HIR\/MOHE\/MED\/25","E0063"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","award":["UM.C\/625\/1\/HIR\/MOHE\/MED\/25","E0063"],"award-info":[{"award-number":["UM.C\/625\/1\/HIR\/MOHE\/MED\/25","E0063"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pathogens"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Fulminant hepatitis (FH) is a life-threatening liver disease characterised by intense immune attack and massive liver cell death. The common precore stop codon mutation of hepatitis B virus (HBV), A1896, is frequently associated with FH, but lacks specificity. This study attempts to uncover all possible viral nucleotides that are specifically associated with FH through a compiled sequence analysis of FH and non-FH cases from acute infection. We retrieved 67 FH and 280 acute non-FH cases of hepatitis B from GenBank and applied support vector machine (SVM) model to seek candidate nucleotides highly predictive of FH. Six best candidates with top predictive accuracy, 92.5%, were used to build a SVM model; they are C2129 (85.3%), T720 (83.0%), Y2131 (82.4%), T2013 (82.1%), K2048 (82.1%), and A2512 (82.1%). This model gave a high specificity (99.3%), positive predictive value (95.6%), and negative predictive value (92.1%), but only moderate sensitivity (64.2%). We successfully built a SVM model comprising six variants that are highly predictive and specific for FH: four in the core region and one each in the polymerase and the surface regions. These variants indicate that intracellular virion\/core retention could play an important role in the progression to FH.<\/jats:p>","DOI":"10.1155\/2017\/1231204","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T23:30:31Z","timestamp":1513726231000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Novel Genetic Variants of Hepatitis B Virus in Fulminant Hepatitis"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2104-761X","authenticated-orcid":true,"given":"Jack Bee","family":"Chook","sequence":"first","affiliation":[{"name":"Sunway Institute for Healthcare Development (SIHD), Sunway University, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Fong","family":"Ngeow","sequence":"additional","affiliation":[{"name":"Department of Pre-Clinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul 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