{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:23:33Z","timestamp":1792023813003,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Planned Projects of Wenzhou City","award":["Y20140669"],"award-info":[{"award-number":["Y20140669"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. Acute-on-chronic liver failure (ACLF) and acute liver failure (ALF) are similar in many respects during their acute exacerbation; however, ACLF generally has a poorer prognosis. We aimed to investigate the role and dynamic changes of regulatory T cell (Treg) and T helper 17 (Th17) cell proportions during ACLF progress.<jats:italic>Methods<\/jats:italic>. All rats were classified into two groups randomly: ACLF group and ALF group (control group). The rat model of ACLF was preestablished by intraperitoneal injection of carbon tetrachloride for 2 months. Then acute liver injury was induced by combined D-galactosamine and lipopolysaccharide. Six time points were examined before or after acute induction. Liver samples were performed with hematoxylin-eosin and Masson staining; circulatory Treg and Th17 cell frequencies were determined using flow cytometry assays; serum levels of alanine aminotransferase, aspartate aminotransferase, interleukin-10 (IL-10), and interferon-<jats:italic>\u03b3<\/jats:italic>(IFN-<jats:italic>\u03b3<\/jats:italic>) were examined.<jats:italic>Results<\/jats:italic>. In group ACLF, both Th17 cell proportion and IFN-<jats:italic>\u03b3<\/jats:italic>level presented upgrade firstly and then descend latter tendency; the trends of Treg cell proportion and IL-10 level were observed to gradually decrease and became stable.<jats:italic>Conclusion<\/jats:italic>. The Treg cells played an important role in the immunologic mechanism during the process of ACLF. And the function of Treg cells in ACLF was defective.<\/jats:p>","DOI":"10.1155\/2017\/1390458","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T21:01:08Z","timestamp":1484514068000},"page":"1-10","source":"Crossref","is-referenced-by-count":25,"title":["Deregulation of Regulatory T Cells in Acute-on-Chronic Liver Failure: A Rat Model"],"prefix":"10.1155","volume":"2017","author":[{"given":"Shunlan","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Key Laboratory of Hepatology, Hepatology Institute of Wenzhou Medical University, Wenzhou, Zhejiang, 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