{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:47Z","timestamp":1787017727843,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n                    <jats:italic>Background.<\/jats:italic>\n                    Pediatric inflammatory bowel disease (IBD) is on the rise worldwide. Endoscopies are necessary for IBD assessment but are invasive, expensive, and inconvenient. Recently, fecal calprotectin (FCal) was proposed as a noninvasive and specific marker of gut inflammation. We evaluated the analytical performance of three FCal assays and their clinical performance in predicting relapse in pediatric IBD.\n                    <jats:italic>Methods.<\/jats:italic>\n                    This study used 40 pediatric IBD and 40 random non-IBD patients\u2019 fecal samples. Two automated ELISAs (B\u00fchlmann and PhiCal\u00ae Calprotectin-EIA) and an EliA (Phadia 250 EliA-Calprotectin) were used to evaluate the analytical performance. The clinical performance was assessed by PhiCal Calprotectin-EIA, EliA-Calprotectin, and B\u00fchlmann immunochromatographic point-of-care test (POCT).\n                    <jats:italic>Results.<\/jats:italic>\n                    All assays displayed acceptable analytical performance below and above the medical decision cut-off [imprecision (CV &lt; 10% intra-assay; &lt;15% interassay); linearity (overall mean % deviation &lt; 16.5%)]. The agreement with PhiCal Calprotectin-EIA was 100% and 78.6% for B\u00fchlmann (95% CI, 87.5\u2013100; Kappa: 1) and EliA-Calprotectin (95% CI, 60.5\u201389.8; Kappa: 0.32), respectively, and 63.6% between B\u00fchlmann and EliA-Calprotectin (95% CI, 46.6\u201377.8; Kappa: 0.16). All assays evaluated had similar clinical performance [AUC: 0.84 (EliA-Calprotectin); 0.83 (POCT and PhiCal Calprotectin-EIA)].\n                    <jats:italic>Conclusion.<\/jats:italic>\n                    FCal levels determined using the same method and assay together with clinical history would be a noninvasive and useful tool in monitoring pediatric IBD.\n                  <\/jats:p>","DOI":"10.1155\/2017\/1450970","type":"journal-article","created":{"date-parts":[[2017,4,16]],"date-time":"2017-04-16T17:00:24Z","timestamp":1492362024000},"page":"1-10","source":"Crossref","is-referenced-by-count":33,"title":["Comparison of Fecal Calprotectin Methods for Predicting Relapse of Pediatric Inflammatory Bowel Disease"],"prefix":"10.1155","volume":"2017","author":[{"given":"Saranya","family":"Kittanakom","sequence":"first","affiliation":[{"name":"Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada L8S 4K1"},{"name":"Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Sharif","family":"Shajib","sequence":"additional","affiliation":[{"name":"Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada L8S 4K1"},{"name":"Farncombe Family Digestive Health Research Institute, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Garvie","sequence":"additional","affiliation":[{"name":"Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joceline","family":"Turner","sequence":"additional","affiliation":[{"name":"Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Brooks","sequence":"additional","affiliation":[{"name":"Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufian","family":"Odeh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Issenman","sequence":"additional","affiliation":[{"name":"Farncombe Family Digestive Health Research Institute, Hamilton, ON, Canada"},{"name":"Division of Pediatric Gastroenterology, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Tony","family":"Chetty","sequence":"additional","affiliation":[{"name":"Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada L8S 4K1"},{"name":"Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Macri","sequence":"additional","affiliation":[{"name":"Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada L8S 4K1"},{"name":"Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6282-9514","authenticated-orcid":true,"given":"Waliul I.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada L8S 4K1"},{"name":"Farncombe Family Digestive Health Research Institute, Hamilton, ON, Canada"},{"name":"Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/984575"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000262"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000187818.76954.9a"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03184.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2347-5"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1983.tb07522.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22861"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322009000500009"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3109\/00365529209011186"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/542363"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9310-8"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318253cff1"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0b013e31810e75a9"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20472"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i2.363"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1586\/eci.12.50"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.05.008"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01126.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.4945"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2013.879732"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.987809"},{"issue":"4","key":"22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/00005176-199105000-00005","volume":"12","year":"1991","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.02.047"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.143"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.06.001"},{"key":"26","series-title":"CLSI Document EP9-A2","volume":"22, no. 19","year":"2002"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.741619"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20376"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22896"},{"issue":"55","key":"30","first-page":"1","volume":"17","year":"2013","journal-title":"Health Technology Assessment"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2012.011272"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2013-0699"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20275"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.560680"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.043406"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i46.6782"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20214"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1373\/49.6.861"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.4.506"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2013-100420"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1097\/mib.0000000000000057"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e3182807577"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.06.028"}],"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2017\/1450970.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2017\/1450970.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2017\/1450970.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T23:11:03Z","timestamp":1569021063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cjgh\/2017\/1450970\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":43,"alternative-id":["1450970","1450970"],"URL":"https:\/\/doi.org\/10.1155\/2017\/1450970","relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"value":"2291-2789","type":"print"},{"value":"2291-2797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}