{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:54:05Z","timestamp":1787162045695,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n                    <jats:italic>Purpose<\/jats:italic>\n                    . To check whether primary involvement of brain\/spinal cord by bone\/soft tissue sarcomas\u2019 metastases in children is as rare as described and to present various morphological forms of bone\/soft tissue sarcomas\u2019 CNS metastases.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Patients with first diagnosis in 1999\u20132014 treated at single center were included with whole course of disease evaluation. Brain\/spinal canal magnetic resonance imaging (MRI)\/computed tomography were performed in cases suspicious for CNS metastases. Extension from skull\/vertebral column metastases was excluded.\n                    <jats:italic>Results<\/jats:italic>\n                    . 550 patients were included. MRI revealed CNS metastases in 19 patients (incidence 3.45%), 14 boys, aged 5\u201322 years. There were 12\/250 osteosarcoma cases, 2\/200 Ewing\u2019s sarcoma, 1\/50 chondrosarcoma, 3\/49 rhabdomyosarcoma (RMS), and 1\/1 malignant mesenchymoma. There were 10 single metastases and 7 cases of multiple ones; in 2 RMS cases only leptomeningeal spread in brain and spinal cord was found. Calcified metastases were found in 3 patients and hemorrhagic in 4. In one RMS patient there were numerous solid, cystic, hemorrhagic lesions and leptomeningeal spread.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . CNS metastases are rare and late in children with bone\/soft tissue sarcomas, although in our material more frequent (3.45%) than in other reports (0.7%). Hematogenous spread to brain and hemorrhagic and calcified lesions dominated in osteosarcoma. Ewing sarcoma tended to metastasize to skull bones. Soft tissue sarcomas presented various morphological forms.\n                  <\/jats:p>","DOI":"10.1155\/2017\/1456473","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T16:00:33Z","timestamp":1485273633000},"page":"1-9","source":"Crossref","is-referenced-by-count":20,"title":["CNS Metastases from Bone and Soft Tissue Sarcomas in Children, Adolescents, and Young Adults: Are They Really So Rare?"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1787-3425","authenticated-orcid":true,"given":"Monika","family":"Bekiesinska-Figatowska","sequence":"first","affiliation":[{"name":"Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Duczkowska","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Duczkowski","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Bragoszewska","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Romaniuk-Doroszewska","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Iwanowska","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, 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