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We investigated the systemic expression of immune-related genes in T2D, dyslipidemia, and CP patients. One hundred and fifty patients were separated into five groups containing 30 individuals each: (G1) poorly controlled T2D with dyslipidemia and CP; (G2) well-controlled T2D with dyslipidemia and CP; (G3) normoglycemic individuals with dyslipidemia and CP; (G4) healthy individuals with CP; (G5) systemic and periodontally healthy individuals. Blood analyses of lipid and glycemic profiles were carried out. The expression of genes, including<jats:italic>IL10, JAK1, STAT3, SOCS3, IP10, ICAM1, IFNA, IFNG, STAT1,<\/jats:italic>and<jats:italic>IRF1,<\/jats:italic>was investigated by RT-qPCR. Patients with dyslipidemia demonstrated statistically higher expression of the<jats:italic>IL10<\/jats:italic>and<jats:italic>IFNA<\/jats:italic>genes, while<jats:italic>IFNG, IP10, IRF1, JAK1,<\/jats:italic>and<jats:italic>STAT3<\/jats:italic>were lower in comparison with nondyslipidemic patients. Anti-inflammatory genes, such as<jats:italic>IL10<\/jats:italic>, positively correlated with parameters of glucose, lipid, and periodontal profiles, while proinflammatory genes, such as<jats:italic>IFNG<\/jats:italic>, were negatively correlated with these parameters. We conclude that dyslipidemia appears to be the primary disease that is associated with gene expression of immune-related genes, while parameters of T2D and CP were correlated with the expression of these important immune genes.<\/jats:p>","DOI":"10.1155\/2017\/1491405","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T21:00:49Z","timestamp":1487624449000},"page":"1-14","source":"Crossref","is-referenced-by-count":11,"title":["Dyslipidemia rather than Type 2 Diabetes Mellitus or Chronic Periodontitis Affects the Systemic Expression of Pro- and Anti-Inflammatory Genes"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3120-0617","authenticated-orcid":true,"given":"Rafael","family":"Nepomuceno","sequence":"first","affiliation":[{"name":"Department of Morphology, School of Dentistry at Araraquara, S\u00e3o Paulo State University (UNESP), 14801-903 Araraquara, SP, 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