{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:50:07Z","timestamp":1787017807626,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Baltimore Veterans Affairs Medical Center Geriatric Research, Education and Clinical Center","award":["P30-DK072488"],"award-info":[{"award-number":["P30-DK072488"]}]},{"name":"Baltimore Veterans Affairs Medical Center Geriatric Research, Education and Clinical Center","award":["NIH P30-AG028747"],"award-info":[{"award-number":["NIH P30-AG028747"]}]},{"name":"Baltimore Veterans Affairs Medical Center Geriatric Research, Education and Clinical Center","award":["NIH K23-AG040775"],"award-info":[{"award-number":["NIH K23-AG040775"]}]},{"name":"Mid-Atlantic Nutrition Obesity Research Center","award":["P30-DK072488"],"award-info":[{"award-number":["P30-DK072488"]}]},{"name":"Mid-Atlantic Nutrition Obesity Research Center","award":["NIH P30-AG028747"],"award-info":[{"award-number":["NIH P30-AG028747"]}]},{"name":"Mid-Atlantic Nutrition Obesity Research Center","award":["NIH K23-AG040775"],"award-info":[{"award-number":["NIH K23-AG040775"]}]},{"name":"University of Maryland Claude D. 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Pepper Center","award":["NIH K23-AG040775"],"award-info":[{"award-number":["NIH K23-AG040775"]}]},{"name":"VA Senior Research Career Scientist Award","award":["P30-DK072488"],"award-info":[{"award-number":["P30-DK072488"]}]},{"name":"VA Senior Research Career Scientist Award","award":["NIH P30-AG028747"],"award-info":[{"award-number":["NIH P30-AG028747"]}]},{"name":"VA Senior Research Career Scientist Award","award":["NIH K23-AG040775"],"award-info":[{"award-number":["NIH K23-AG040775"]}]},{"name":"VA Career Development Award","award":["P30-DK072488"],"award-info":[{"award-number":["P30-DK072488"]}]},{"name":"VA Career Development Award","award":["NIH P30-AG028747"],"award-info":[{"award-number":["NIH P30-AG028747"]}]},{"name":"VA Career Development Award","award":["NIH K23-AG040775"],"award-info":[{"award-number":["NIH K23-AG040775"]}]},{"name":"Paul B. Beeson Patient-Oriented Research Career Development Award in Aging","award":["P30-DK072488"],"award-info":[{"award-number":["P30-DK072488"]}]},{"name":"Paul B. Beeson Patient-Oriented Research Career Development Award in Aging","award":["NIH P30-AG028747"],"award-info":[{"award-number":["NIH P30-AG028747"]}]},{"name":"Paul B. Beeson Patient-Oriented Research Career Development Award in Aging","award":["NIH K23-AG040775"],"award-info":[{"award-number":["NIH K23-AG040775"]}]},{"name":"VA Merit Review Award","award":["P30-DK072488"],"award-info":[{"award-number":["P30-DK072488"]}]},{"name":"VA Merit Review Award","award":["NIH P30-AG028747"],"award-info":[{"award-number":["NIH P30-AG028747"]}]},{"name":"VA Merit Review Award","award":["NIH K23-AG040775"],"award-info":[{"award-number":["NIH K23-AG040775"]}]},{"name":"VA Advanced Research Career Development Award","award":["P30-DK072488"],"award-info":[{"award-number":["P30-DK072488"]}]},{"name":"VA Advanced Research Career Development Award","award":["NIH P30-AG028747"],"award-info":[{"award-number":["NIH P30-AG028747"]}]},{"name":"VA Advanced Research Career Development Award","award":["NIH K23-AG040775"],"award-info":[{"award-number":["NIH K23-AG040775"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n                    Aerobic exercise training and weight loss (AEX+WL) improves insulin sensitivity in overweight adults; however, the underlying pathways are incompletely understood. Fetuin-A, a hepatokine that inhibits insulin signaling, may be involved in the salutary effects of AEX+WL. Therefore, we examined the effects of 6-month AEX+WL on plasma fetuin-A levels (36\u201348 hours after the last bout of exercise), aerobic capacity (VO\n                    <jats:sub>2max<\/jats:sub>\n                    ), body composition, glucose tolerance, and insulin sensitivity (M) in 16 sedentary, overweight-obese older men (age\u2009=\u200960\u2009\u00b1\u20092 years, BMI\u2009=\u200931\u2009\u00b1\u20091\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) with no history of cardiovascular disease or diabetes. At baseline, fetuin-A levels correlated directly with adiposity and had a borderline inverse correlation with M. After AEX+WL, body weight decreased by ~10\u2009kg, while both VO\n                    <jats:sub>2max<\/jats:sub>\n                    and M increased by 16% (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.005<\/mml:mn>\n                    <\/mml:math>\n                    for all). Contrary to our hypothesis, plasma fetuin-A levels increased after AEX+WL (1.16\u2009\u00b1\u20090.10\u2009g\/L versus 1.70\u2009\u00b1\u20090.19\u2009g\/L,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.006<\/mml:mn>\n                    <\/mml:math>\n                    ). This increase was unrelated to changes in body composition or glucose metabolism, but directly correlated with changes in VO\n                    <jats:sub>2max<\/jats:sub>\n                    (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mi>r<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.57<\/mml:mn>\n                    <\/mml:math>\n                    ,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                    <\/mml:math>\n                    ). Thus, in overweight-to-obese older men, AEX+WL appears to increase plasma fetuin-A levels. Although not associated with improvements in insulin sensitivity, this increase in fetuin-A was related to improvements in aerobic capacity and could be representative of the cardioprotective effects of AEX+WL in older men.\n                  <\/jats:p>","DOI":"10.1155\/2017\/1492581","type":"journal-article","created":{"date-parts":[[2017,7,9]],"date-time":"2017-07-09T17:04:19Z","timestamp":1499619859000},"page":"1-7","source":"Crossref","is-referenced-by-count":17,"title":["Effects of Exercise Training and Weight Loss on Plasma Fetuin-A Levels and Insulin Sensitivity in Overweight Older Men"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4193-1536","authenticated-orcid":true,"given":"Jacob B.","family":"Blumenthal","sequence":"first","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA"},{"name":"Baltimore Veterans Affairs Geriatric Research, Education and Clinical Center and Research and Development Service, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gitterman","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA"},{"name":"Baltimore Veterans Affairs Geriatric Research, Education and Clinical Center and Research and Development Service, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice S.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA"},{"name":"Baltimore Veterans Affairs Geriatric Research, Education and Clinical Center and Research and Development Service, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4627-6489","authenticated-orcid":true,"given":"Steven J.","family":"Prior","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA"},{"name":"Baltimore Veterans Affairs Geriatric Research, Education and Clinical Center and Research and Development Service, Baltimore, MD, 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