{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:47:22Z","timestamp":1790693242796,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012465","name":"Dalian Medical University","doi-asserted-by":"crossref","award":["2015010"],"award-info":[{"award-number":["2015010"]}],"id":[{"id":"10.13039\/501100012465","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012465","name":"Dalian Medical University","doi-asserted-by":"crossref","award":["81671606"],"award-info":[{"award-number":["81671606"]}],"id":[{"id":"10.13039\/501100012465","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012465","name":"Dalian Medical University","doi-asserted-by":"crossref","award":["81373214"],"award-info":[{"award-number":["81373214"]}],"id":[{"id":"10.13039\/501100012465","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2015010"],"award-info":[{"award-number":["2015010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671606"],"award-info":[{"award-number":["81671606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373214"],"award-info":[{"award-number":["81373214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2015010"],"award-info":[{"award-number":["2015010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671606"],"award-info":[{"award-number":["81671606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373214"],"award-info":[{"award-number":["81373214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Rheumatoid arthritis (RA) is a chronic autoimmune disease which is characterized by synovial inflammation and cartilage damage for which causes articular dysfunction. Activation of fibroblast-like synoviocytes (FLS) is a critical step that promotes disease progression. In this study, we aimed to explore the effect of interleukin-34 (IL-34) on RA FLS as a proinflammatory factor and IL-34-stimulated FLS on the production of Th17. We found that serum IL-34 levels were increased compared to those of the healthy controls and had positive correlations with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), and anticyclic citrullinated peptide (CCP) antibody accordingly. CSF-1R was also highly expressed on RA FLS. The interaction of IL-34 and CSF-1R promoted a dramatic production of IL-6 by FLS through JNK\/P38\/NF-<jats:italic>\u03ba<\/jats:italic>B signaling pathway. Further, the IL-34-stimulated IL-6 secretion by RA FLS was found to upregulate the number of Th17. The treatment of IL-6R antagonist could attenuate the production of Th17 mediated by IL-34-stimulated RA FLS. Our results suggest that the increased IL-34 levels were closely related to the disease activity of RA. Additionally, the overexpression of IL-6 in the IL-34-stimulated FLS promoted the generation of Th17. Therefore, IL-34 was supposed to be involved in the pathogenesis of RA. The inhibition of IL-34 might provide a novel target for therapies of RA.<\/jats:p>","DOI":"10.1155\/2017\/1567120","type":"journal-article","created":{"date-parts":[[2017,6,4]],"date-time":"2017-06-04T21:02:38Z","timestamp":1496610158000},"page":"1-10","source":"Crossref","is-referenced-by-count":31,"title":["IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5953-6198","authenticated-orcid":true,"given":"Bing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital of Hebei Medical University, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Microecology, College of Basic Medical Science, Dalian Medical University, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Second Affiliated Hospital of Dalian Medical University, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4402-2386","authenticated-orcid":true,"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0205-6732","authenticated-orcid":true,"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000148"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/nri2094"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154370"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-013-0476-3"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1209822"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2360"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2015.06.019"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.05.016"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021857"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081665"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344365"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes435"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv181"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/ar3693"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2012.0122"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200096"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1688-7"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2013.04.014"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130356"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3056-5"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029515"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110340"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/765624"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12334"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103201"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2012.666845"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20140141"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.10.001"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290257"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2014.05.004"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22540"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-015-9477-2"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-011-6368-7"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.07.1117"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051916"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2017\/1567120.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2017\/1567120.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2017\/1567120.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T23:38:44Z","timestamp":1589758724000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2017\/1567120\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":36,"alternative-id":["1567120","1567120"],"URL":"https:\/\/doi.org\/10.1155\/2017\/1567120","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}