{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:49:33Z","timestamp":1792000173903,"version":"4.4.0"},"reference-count":73,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>The present work was designed to investigate the antibacterial activities of methanol extracts from six Cameroonian edible plants and their synergistic effects with some commonly used antibiotics against multidrug-resistant (MDR) Gram-negative bacteria expressing active efflux pumps. The extracts were subjected to qualitative phytochemical screening and the microdilution broth method was used for antibacterial assays. The results of phytochemical tests indicate that all tested crude extracts contained polyphenols, flavonoids, triterpenes, and steroids. Extracts displayed selective antibacterial activities with the minimal inhibitory concentration (MIC) values ranging from 32 to 1024\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL. The lowest MIC value (32\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) was recorded with<jats:italic>Coula edulis<\/jats:italic>extract against<jats:italic>E. coli<\/jats:italic>AG102 and<jats:italic>K. pneumoniae<\/jats:italic>K2 and with<jats:italic>Mangifera indica<\/jats:italic>bark extract against<jats:italic>P. aeruginosa<\/jats:italic>PA01 and<jats:italic>Citrus sinensis<\/jats:italic>extract against<jats:italic>E. coli<\/jats:italic>W3110 which also displayed the best MBC (256\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) value against<jats:italic>E. coli<\/jats:italic>ATCC8739. In combination with antibiotics, extracts from<jats:italic>M. indica<\/jats:italic>leaves showed synergistic effects with 75% (6\/8) of the tested antibiotics against more than 80% of the tested bacteria. The findings of the present work indicate that the tested plants may be used alone or in combination in the treatment of bacterial infections including the multidrug-resistant bacteria.<\/jats:p>","DOI":"10.1155\/2017\/1583510","type":"journal-article","created":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T21:01:59Z","timestamp":1503262919000},"page":"1-19","source":"Crossref","is-referenced-by-count":73,"title":["Antibacterial and Antibiotic-Modifying Activity of Methanol Extracts from Six Cameroonian Food Plants against Multidrug-Resistant Enteric Bacteria"],"prefix":"10.1155","volume":"2017","author":[{"given":"Joachim K.","family":"Dzotam","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, 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