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Slowly growing mycobacteria (SGM) are prevalent worldwide and cause an extensive spectrum of diseases.<jats:italic> Methods<\/jats:italic>. In this study, the antimicrobial susceptibility of 33 reference strains of SGM to 19 antimicrobial agents was tested using a modified microdilution method.<jats:italic> Results<\/jats:italic>. Cefmetazole (32\/33) and azithromycin (32\/33) exhibited the highest antimicrobial activity, and dapsone (9\/33) exhibited the lowest activity against the tested strains. Cefoxitin (30\/33), cefoperazone (28\/33), and cefepime (28\/33) were effective against a high proportion of strains, and macrolides were also highly effective as well as offering the benefit of convenient oral administration to patients. Linezolid (27\/33), meropenem (26\/33), sulfamethoxazole (26\/33), and tigecycline (25\/33) showed the highest activity; clofazimine (20\/33) and doxycycline (18\/33) showed intermediate activity; and rifapentine (13\/33), rifabutin (13\/33), and minocycline (11\/33) showed low antimicrobial activity, closely followed by thioacetazone (10\/33) and pasiniazid (10\/33), against the tested organisms. According to their susceptibility profiles, the slowly growing species<jats:italic> Mycobacterium avium<\/jats:italic> and<jats:italic> Mycobacterium simiae<\/jats:italic> were the least susceptible to the tested drugs, whereas<jats:italic> Mycobacterium intracellulare<\/jats:italic>,<jats:italic> Mycobacterium asiaticum<\/jats:italic>,<jats:italic> Mycobacterium scrofulaceum<\/jats:italic>,<jats:italic> Mycobacterium szulgai<\/jats:italic>,<jats:italic> Mycobacterium branderi<\/jats:italic>, and<jats:italic> Mycobacterium holsaticum<\/jats:italic> were the most susceptible.<jats:italic> Conclusions<\/jats:italic>. In summary, cephalosporins and macrolides, particularly cefmetazole, azithromycin, clarithromycin, and roxithromycin, showed good antimicrobial activity against the reference strains of SGM.<\/jats:p>","DOI":"10.1155\/2017\/1584658","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T17:00:41Z","timestamp":1492707641000},"page":"1-13","source":"Crossref","is-referenced-by-count":10,"title":["Drug Susceptibility of 33 Reference Strains of Slowly Growing Mycobacteria to 19 Antimicrobial Agents"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8526-9329","authenticated-orcid":true,"given":"Hui","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Immunology, Changzhi Medical College, Changzhi, Shanxi 046000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Infectious Disease 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