{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:39:25Z","timestamp":1762659565077,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background and Aims.<\/jats:italic> To establish the efficacy and safety of ilaprazole, levofloxacin, and amoxicillin as a first-line eradication treatment for <jats:italic>Helicobacter pylori<\/jats:italic>. <jats:italic>Methods.<\/jats:italic> Patients with gastric ulcer, duodenal ulcer, or gastritis, as detected by esophagogastroduodenoscopy with confirmed <jats:italic>H. pylori<\/jats:italic> infection between September 2014 and November 2015, were enrolled in the study. All participants received ilaprazole (10\u2009mg bid), levofloxacin (500\u2009mg bid), and amoxicillin (1000\u2009mg bid) for 10 days. <jats:italic>H. pylori<\/jats:italic> eradication was confirmed by a <jats:sup>13<\/jats:sup>C-urea breath test at 6\u20138 weeks after the end of treatment. <jats:italic>Results.<\/jats:italic> Of 84 patients included in the analysis, the eradication rate was 88.8% in the per protocol group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>80<\/mml:mn><\/mml:math>). Demographic factors such as age, gender, body mass index (BMI), alcohol, smoking, hypertension, diabetes mellitus, and peptic ulcer did not affect the eradication rate. However, multivariate analysis showed that overweight patients and patients with cerebrovascular accident (CVA) had a significantly lower eradication rate than patients with normal BMI and without CVA. Laboratory test results did not change significantly after treatment. A total of six (7.5%) patients developed eight adverse reactions. <jats:italic>Conclusions.<\/jats:italic> A 10-day triple therapy containing ilaprazole, levofloxacin, and amoxicillin is a safe alternative first-line eradication treatment for <jats:italic>H. pylori<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/2017\/1654907","type":"journal-article","created":{"date-parts":[[2017,4,30]],"date-time":"2017-04-30T17:00:37Z","timestamp":1493571637000},"page":"1-6","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and Safety of the Triple Therapy Containing Ilaprazole, Levofloxacin, and Amoxicillin as First-Line Treatment in <i>Helicobacter pylori<\/i> Infections"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1304-9140","authenticated-orcid":true,"given":"Hyo Jun","family":"Ahn","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Daejeon St. Mary\u2019s Hospital, The Catholic University of Korea, Daejeon 34943, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Pil","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Daejeon St. Mary\u2019s Hospital, The Catholic University of Korea, Daejeon 34943, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myeong Su","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Daejeon St. Mary\u2019s Hospital, The Catholic University of Korea, Daejeon 34943, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon Jeong","family":"Yun","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Daejeon St. Mary\u2019s Hospital, The Catholic University of Korea, Daejeon 34943, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok-Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Daejeon St. Mary\u2019s Hospital, The Catholic University of Korea, Daejeon 34943, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Daejeon St. Mary\u2019s Hospital, The Catholic University of Korea, Daejeon 34943, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9198-0785","authenticated-orcid":true,"given":"Dong Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Daejeon St. 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