{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:47:17Z","timestamp":1774489637894,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The possible sequel of poorly controlled intraocular pressure (IOP) includes treatment failure, unnecessary medication use, and economic burden on patients with glaucoma. <jats:italic>Objective<\/jats:italic>. To assess the impact of adherence and instillation technique on IOP control. <jats:italic>Methods<\/jats:italic>. A cross-sectional study was conducted on 359 glaucoma patients in Menelik II Hospital from June 1 to July 31, 2015. After conducting a Q-Q analysis, multiple binary logistic analyses, linear regression analyses, and two-tailed paired t-test were conducted to compare IOP in the baseline versus current measurements. <jats:italic>Results<\/jats:italic>. Intraocular pressure was controlled in 59.6% of the patients and was relatively well controlled during the study period (mean (<jats:italic>M<\/jats:italic>)\u2009=\u200917.911\u2009mmHg, standard deviation (<jats:italic>S<\/jats:italic>)\u2009=\u20090.323) compared to the baseline (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>M<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>20.866<\/mml:mn><\/mml:math>\u2009mmHg, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>S<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.383<\/mml:mn><\/mml:math>, <jats:italic>t<\/jats:italic> (358)\u2009=\u2009\u22126.70, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>). A unit increase in the administration technique score resulted in a 0.272\u2009mmHg decrease in IOP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.03<\/mml:mn><\/mml:math>). Moreover, primary angle-closure glaucoma (adjusted odds ratio (AOR)\u2009=\u20090.347, 95% confidence interval (CI): 0.144\u20130.836) and two medications (AOR = 1.869, 95% CI: 1.259\u20139.379) were factors affecting IOP. <jats:italic>Conclusion<\/jats:italic>. Good instillation technique of the medications was correlated with a reduction in IOP. Consequently, regular assessment of the instillation technique and IOP should be done for better management of the disease.<\/jats:p>","DOI":"10.1155\/2017\/1683430","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T17:02:33Z","timestamp":1505408553000},"page":"1-8","source":"Crossref","is-referenced-by-count":22,"title":["The Impact of Adherence and Instillation Proficiency of Topical Glaucoma Medications on Intraocular Pressure"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6483-2258","authenticated-orcid":true,"given":"Tesfay Mehari","family":"Atey","sequence":"first","affiliation":[{"name":"Clinical Pharmacy Unit, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Tigray, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Workineh","family":"Shibeshi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeba","family":"T. Giorgis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon Weldegebreal","family":"Asgedom","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Unit, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Tigray, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2147\/opth.s82909"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.11.030"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(04)16257-0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199111143252004"},{"key":"5","first-page":"887","volume":"82","year":"2004","journal-title":"Bulletin of the World Health Organization"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.110605"},{"key":"7","first-page":"168","volume":"2","year":"2009","journal-title":"International Journal Ophthalmology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.07.040"},{"key":"9","first-page":"29","volume":"105","year":"2007","journal-title":"Transactions of the American Ophthalmological Society"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2000.197"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2004.20.461"},{"key":"12","year":"2009"},{"key":"13","first-page":"138","volume":"106","year":"2008","journal-title":"Transactions of the American Ophthalmological Society"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3129\/i08-076"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.10.034"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.96"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.103"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31820bd2e1"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.05.013"},{"key":"20","first-page":"149","volume":"29","year":"2005","journal-title":"Collegium Antropologicum"},{"key":"21","year":"2005"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2008.07572.x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2008.07572.x"},{"key":"24","first-page":"59","volume":"15","year":"2009","journal-title":"The American Journal of Managed Care"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.09.010"},{"key":"26","first-page":"16","volume":"110","year":"2014","journal-title":"Nursing Times"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-016-0316-z"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9570.1000554"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1089\/10807680260362687"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.187"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/1683430.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/1683430.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/1683430.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T17:02:34Z","timestamp":1505408554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/joph\/2017\/1683430\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":30,"alternative-id":["1683430","1683430"],"URL":"https:\/\/doi.org\/10.1155\/2017\/1683430","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}