{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:34:47Z","timestamp":1780583687618,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005952","name":"Ministry of Human Resources and Social Security","doi-asserted-by":"publisher","award":["2014-QTL-028"],"award-info":[{"award-number":["2014-QTL-028"]}],"id":[{"id":"10.13039\/501100005952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005952","name":"Ministry of Human Resources and Social Security","doi-asserted-by":"publisher","award":["2015-QNYC-A-03"],"award-info":[{"award-number":["2015-QNYC-A-03"]}],"id":[{"id":"10.13039\/501100005952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012173","name":"China-Japan Friendship Hospital","doi-asserted-by":"crossref","award":["2014-QTL-028"],"award-info":[{"award-number":["2014-QTL-028"]}],"id":[{"id":"10.13039\/501100012173","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012173","name":"China-Japan Friendship Hospital","doi-asserted-by":"crossref","award":["2015-QNYC-A-03"],"award-info":[{"award-number":["2015-QNYC-A-03"]}],"id":[{"id":"10.13039\/501100012173","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>The recently discovered IL-33 as an IL-1 cytokine family member has been proved to be specifically released from osteonecrotic bones. We aimed to investigate the potential role of IL-33 in the development of osteonecrosis of femoral head (ONFH). Forty patients diagnosed with ONFH and forty age-, sex-, and body mass index- (BMI-) matched healthy subjects were included in this prospective study between March 2016 and September 2016. A commercially available ELISA kit was used to test the level of plasma IL-33. The IL-33 levels were compared among different ARCO stages, CJFH types, and etiology groups. Plasma IL-33 levels were significantly higher in the ONFH patients than that in the control subjects. The levels of IL-33 did not differ significantly among the ONFH patients with different ARCO stages. The IL-33 levels of patients with CJFH type L3 were significantly higher than that of patients with types L1 and L2. No significant differences were observed in IL-33 levels between steroid-induced, alcohol-induced, and idiopathic patients. Our findings seem to indicate that IL-33 effects may be detrimental during ONFH, which appeared to be associated with the prognosis of ONFH. The IL-33 deserves particular attention in the pathogenesis of ONFH.<\/jats:p>","DOI":"10.1155\/2017\/1732638","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T21:01:54Z","timestamp":1484168514000},"page":"1-6","source":"Crossref","is-referenced-by-count":17,"title":["Hip Osteonecrosis Is Associated with Increased Plasma IL-33 Level"],"prefix":"10.1155","volume":"2017","author":[{"given":"Jinhui","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Bone and Joint Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanshou","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China"},{"name":"Department of Bone and Joint Surgery, Center for Osteonecrosis and Joint Preserving & Reconstruction, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China"},{"name":"Department of Bone and Joint Surgery, Center for Osteonecrosis and Joint Preserving & Reconstruction, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3899-1236","authenticated-orcid":true,"given":"Bailiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China"},{"name":"Department of Bone and Joint Surgery, Center for Osteonecrosis and Joint Preserving & Reconstruction, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.168017"},{"issue":"1","key":"2","first-page":"68","volume":"73","year":"1991","journal-title":"Journal of Bone and Joint Surgery - 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